ArticleInternational journal of surgery case reports2025
Case report: Bladder carcinoma with shadow cell differentiation: a case report with immunohistochemical analyses.
Article in International journal of surgery case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pilomatrix-like high grade carcinomas involving urinary bladder: a novel divergent differentiation in urothelial carcinoma.Virchows Archiv : an international journal of pathology · 2026Article
- Wnt/β-catenin-activated rosette-forming carcinoma of the lung: a case report of a possible pulmonary counterpart of a recently recognized cutaneous entity.Virchows Archiv : an international journal of pathology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and importanceBladder carcinoma encompasses various histological subtypes, with shadow cell differentiation (SCD) being an exceptionally rare occurrence, resembling cutaneous pilomatricoma. Herein, we report a case of bladder carcinoma with SCD and aim to elucidate its clinico-pathological characteristics. CASE PRESENTATION: A 67-year-old North African man, a heavy smoker, who presented with left lumbar pain, haematuria and dysuria. The physical examination revealed a hypogastric mass. Rectal examination was unremarkable. Radiological examination (Ultrasound and CT) showed a 3 cm bladder tumor, with a suspicious lung and mediastinal tumors. A complete transurethral resection of the bladder tumor (TURB) was performed. It showed high-grade urothelial carcinoma with partial squamous differentiation and SCD. Immunohistochemistry revealed positive β-catenin in the peripheral squamous component. CLINICAL DISCUSSION: Our findings highlight that SCD, a form of keratinization typically observed in the hair matrix, can also manifest in carcinomas with squamous components. The presence of SCD in these tumors suggests a variant of keratinization potentially linked to the squamous components within these neoplasms.
conclusionWe presented a case bladder carcinoma with SCD, underscoring its unique histopathological features and the importance of recognizing this rare variant for accurate diagnosis and management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.