ReviewChembiochem : a European journal of chemical biology2025
Hijacking the Electron Train: Menaquinone-Binding Antimicrobial Peptides.
Review in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hijacking the Electron Train: Menaquinone-Binding Antimicrobial Peptides.Chembiochem : a European journal of chemical biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rise of antibiotic resistance threatens to undermine modern medicine, making the development of new antibiotics and novel targets an urgent priority. Among emerging strategies, targeting menaquinone (MK), a membrane-bound electron carrier, has gained traction as a promising yet underexplored approach. MK is only used for electron transport in bacteria, making it an attractive, selective antimicrobial target. Since the discovery of the first MK-binding antimicrobial peptide (MBAMP), lysocin E, several other examples, natural and synthetic, have been reported. Given the dire need for new antibiotics that are structurally and mechanistically distinct from anything that has come before, MBAMPs potentially offer new hope in the fight against antimicrobial resistance. This review covers recent advances in the discovery, characterization, synthesis and derivatization, and mechanistic understanding of MBAMPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.