Evidence map›Paper›PMID 40857577›Full record

ArticleACS synthetic biology2025

Sustainable Production of Bio-Based Geraniol: Heterologous Expression of Early Terpenoid Pathway Enzymes in

Federico Perozeni, Edoardo Ceschi, Giovanni Luzzini, Davide Slaghenaufi, Matteo Pivato, Stefano Cazzaniga, Thomas Baier, Alexander Einhaus, Sebastian Overmans, Kyle J Lauersen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Federico PerozeniDepartment of Biotechnology, University of Verona, Strada le Grazie 15, Verona 37134, Italy.
Edoardo CeschiDepartment of Biotechnology, University of Verona, Strada le Grazie 15, Verona 37134, Italy.ORCID 0009-0003-3690-8651
Giovanni LuzziniDepartment of Biotechnology, University of Verona, Strada le Grazie 15, Verona 37134, Italy.
Davide SlaghenaufiDepartment of Biotechnology, University of Verona, Strada le Grazie 15, Verona 37134, Italy.ORCID 0000-0002-4778-2359
Matteo PivatoDepartment of Biotechnology, University of Verona, Strada le Grazie 15, Verona 37134, Italy.ORCID 0000-0002-1168-6357
Stefano CazzanigaDepartment of Biotechnology, University of Verona, Strada le Grazie 15, Verona 37134, Italy.ORCID 0000-0002-2824-7916
Thomas BaierFaculty of Biology, Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstrasse 27, Bielefeld 33615, Germany.ORCID 0000-0002-5226-3035
Alexander EinhausFaculty of Biology, Center for Biotechnology (CeBiTec), Bielefeld University, Universitätsstrasse 27, Bielefeld 33615, Germany.ORCID 0000-0003-4713-3671
Sebastian OvermansBioengineering Program, Biological Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 239555, Saudi Arabia.ORCID 0000-0003-3462-6629
Kyle J LauersenBioengineering Program, Biological Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 239555, Saudi Arabia.ORCID 0000-0002-5538-7201
Maurizio UglianoDepartment of Biotechnology, University of Verona, Strada le Grazie 15, Verona 37134, Italy.ORCID 0000-0002-6487-2866
Matteo BallottariDepartment of Biotechnology, University of Verona, Strada le Grazie 15, Verona 37134, Italy.ORCID 0000-0001-8410-3397

Funding

EUROPEAN Innovation Council 101099476University of Verona JRVR2021BALLOTTARI
6 · The paper itself

Abstract

Geraniol is a monoterpene alcohol with a rose-like aroma, used in food and cosmetics and for its anti-inflammatory, antibacterial, and insect-repellent properties. Geraniol is commonly chemically synthesized from petroleum-based sources in a highly energy-demanding process with a large carbon footprint. Alternatively, geraniol can be derived from plant-based essential oils but with relatively low yields and limitations from seasonal cultivation. Here, a sustainable geraniol biosynthesis alternative was established in the photosynthetic green microalga

Indexed as

Acyclic MonoterpenesChlamydomonas reinhardtiiTerpenesAlkyl and Aryl TransferasesCatharanthusGeranyltranstransferaseMetabolic EngineeringSalviaTransferasesAcyclic MonoterpenesAlkyl and Aryl Transferasesdeoxyxylulose-5-phosphate synthasegeraniolGeranyltranstransferaseTerpenesTransferasesChlamydomonas reinhardtiigeraniolgeraniol synthasegeranyl diphosphate synthasemetabolic engineeringterpenes

Identifiers

PMID40857577
PMCPMC12455652

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.