Evidence map›Paper›PMID 40857535›Full record

ArticleCell biomaterials2025

Ceria-nanocluster based therapy for Alzheimer's disease through the modulation of activated microglia and attenuation of amyloid-β deposition.

Hai-Jun Liu, Mingming Wang, Yuzhen Wang, Shanshan Shi, Xiangxiang Hu, Dong-Bo Zhang, Daping Fan, Jacobo Mintzer, Peisheng Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hai-Jun LiuDepartment of Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
Mingming WangDepartment of Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
Yuzhen WangDepartment of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.
Shanshan ShiDepartment of Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
Xiangxiang HuDepartment of Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
Dong-Bo ZhangGreenbrier High School, Evans, GA 30809, USA.
Daping FanDepartment of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.
Jacobo MintzerCollege of Health Professions, Medical University of South Carolina, Charleston, SC 29425, USA.
Peisheng XuDepartment of Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.

Funding

Brain targeted nanoparticle for Alzheimer's disease therapyR01AG054839 · NIA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI XU, PEISHENG · 2017 to 2021
$1.8M
Cancer cell selective killing nanoparticle for advanced ovarian cancer treatmentR01CA263747 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Peisheng Xu · 2022 to 2026
$1.7M
Develop a novel strategy to deliver N-acetylcysteine for AD treatmentR41AG087769 · NIA · ACEPRE, LLC · PI FAN, DAPING, XU, PEISHENG · 2024 to 2024
$499k
NCI NIH HHS R01 CA263747NIA NIH HHS R01 AG054839NIA NIH HHS R41 AG087769
6 · The paper itself

Abstract

Despite extensive efforts dedicated to developing therapies for Alzheimer's disease (AD), we still lack effective approaches capable of curing or halting its progression. Mounting evidence highlights the critical roles of dysfunctional microglia, which promote the abnormal accumulation of harmful protein deposits and initiate aggressive neuroinflammation, contributing to both the onset and advancement of AD. Hereby, we develop a brain-

Identifiers

PMID40857535
PMCPMC12364118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.