Evidence map›Paper›PMID 40857458›Full record

ArticleThe journal of positive psychology2024

Dispositional Optimism Predicts Antidepressant Treatment Response in Major Depressive Disorder: Potential Relevance for Positive Psychology Interventions.

Ari S Coopersmith, Owen M Wolkowitz, Sindy H Mellon, Gwyneth Wu, Ryan Rampersaud, Nicholas Hansen, Ethan G Dutcher, Victor I Reus, Stefanie E Mayer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of positive psychology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ari S CoopersmithDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Owen M WolkowitzDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Sindy H MellonDepartment of OB-GYN and Reproductive Sciences, UCSF School of Medicine, San Francisco, CA, USA.
Gwyneth WuDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Ryan RampersaudDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Nicholas HansenDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Ethan G DutcherDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Victor I ReusDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Stefanie E MayerDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.

Funding

Cell Aging in Major DepressionR01MH083784 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S., MELLON, SYNTHIA H · 2010 to 2020
$6.7M
Training the Next Generation of Psychiatrists-Scientists for Translational ResearchR25MH129256 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANTONIA S NEW, Maria De Las Mercedes Perez Rodriguez · 2023 to 2026
$831k
Understanding and Reversing the Effects of Early Life Adversity on Midlife Health: Improving Daily Psychological Stress Responses using an Ecological Momentary InterventionR00AG062778 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAYER, STEFANIE EVA · 2021 to 2023
$747k
NIA NIH HHS R00 AG062778NIMH NIH HHS R01 MH083784NIMH NIH HHS R25 MH129256
6 · The paper itself

Abstract

Positive psychology interventions have demonstrated efficacy in treating Major Depressive Disorder (MDD), but the relationship between dispositional optimism and antidepressant treatment response remains unclear. In this study, optimism (Revised Life Orientation Test, LOT-R) and depression severity (Hamilton Depression Rating Scale, HDRS) were assessed in healthy unmedicated MDD participants (N=86) and healthy controls (N=65). Treatment response (≥50% reduction in HDRS) was measured in 46 of these MDD participants after 8 weeks of open-label selective serotonin reuptake inhibitor (SSRI) treatment. MDD participants reported significantly lower pre-treatment optimism than healthy controls. Higher pre-treatment optimism, as well as greater increase in optimism (pre-treatment to 8 weeks), were associated with greater likelihood of being an SSRI responder versus non-responder (

Indexed as

Antidepressant Treatment ResponseDispositional OptimismMajor Depressive DisorderPositive PsychologySelective Serotonin Reuptake Inhibitor (SSRI)

Identifiers

PMID40857458
PMCPMC12333585

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.