ArticleBioconjugate chemistry2025
Biophysical and Biochemical Characterization of PEGylated High-Molecular-Weight Relaxed and Tense Quaternary State Polymerized Human Hemoglobin.
Article in Bioconjugate chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Hemoglobin-based oxygen carriers with antioxidant properties.Journal of materials chemistry. B · 2026Article
- Biophysical and Biochemical Characterization of High Molecular Weight Co-Polymerized Human Hemoglobin and Albumin as a Potential Hemoglobin-Based Oxygen Carrier.ACS biomaterials science & engineering · 2026Article
- Scalable production and biophysical characterization of an enzyme cocktail derived from human red blood cells.Biotechnology progressArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the biophysical properties of PEGylated hemoglobin-based oxygen carriers (HBOCs), including PEGylated human hemoglobin (hHb) and tense (T) and relaxed (R) quaternary state polymerized human hemoglobins (PolyhHbs), to potentially improve their safety and efficacy as red blood cell substitutes. PEGylation slightly increased autoxidation in all variants compared to their precursors (hHb and T- and R-state PolyhHb). PEG-hHb showed elevated heme release, while PEGylated PolyhHbs retained a similar heme release compared to their precursors. The thermal stability of PEGylated variants was maintained compared to their precursors, indicating a preserved structural integrity. PEG-T-state PolyhHb maintained a low oxygen affinity (
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