Evidence map›Paper›PMID 40857323›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

STAGE: A compact and versatile TnpB-based genome editing toolkit for

Jing Luo, Natalie Chia, Yuxi Qin, Pan Tan, Lingwen Zhang, Sihan Yang, Zihan Yuan, Liang Hong, Sang Yup Lee, Yaojun Tong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Stepwise DNA unwinding gates TnpB genome-editing activity.bioRxiv : the preprint server for biology · 2026
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing Luo *State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Natalie Chia *State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-7553-9268
Yuxi Qin *State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Pan Tan *School of Physics and Astronomy, and Shanghai National Center for Applied Mathematics (Shanghai Jiao Tong University Center), and Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
Lingwen ZhangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Sihan YangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Zihan YuanState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Liang HongSchool of Physics and Astronomy, and Shanghai National Center for Applied Mathematics (Shanghai Jiao Tong University Center), and Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
Sang Yup LeeMetabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0003-0599-3091
Yaojun TongState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-4042-2462

Funding

Ministry of Science and ICT, South Korea (MSIT) 2022M3J5A1056117MOST | National Key Research and Development Program of China (NKPs) 2021YFA0909500Science and Technology Commission of Shanghai Municipality (STCSM) 24HC2810200Shanghai Pilot Program for Basic Research 21TQ1400204State Key Laboratory of Microbial Metabolism (SKLMM) MMLKF22-03
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ProteinsGene EditingGenome, BacterialStreptomycesCRISPR-Cas SystemsMultigene FamilyBacterial Proteinsbase editinggenome editingmultiplexed genome editingStreptomycesTnpB

Identifiers

PMID40857323
PMCPMC12415229

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.