Evidence map›Paper›PMID 40857319›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling.

Ferdinand Horvath, Hendrik Jung, Herwig Grabmayr, Marc Fahrner, Christoph Romanin, Gerhard Hummer

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The CaCell reports. Medicine · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ferdinand HorvathInstitute of Theoretical Physics, Johannes Kepler University Linz, 4040 Linz, Austria.ORCID 0000-0002-4441-3195
Hendrik JungDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.ORCID 0000-0002-2159-0391
Herwig GrabmayrInstitute of Biophysics, Johannes Kepler University Linz, 4020 Linz, Austria.ORCID 0000-0003-0870-5833
Marc FahrnerInstitute of Biophysics, Johannes Kepler University Linz, 4020 Linz, Austria.ORCID 0000-0002-2689-0158
Christoph RomaninInstitute of Biophysics, Johannes Kepler University Linz, 4020 Linz, Austria.ORCID 0000-0003-3756-4136
Gerhard HummerDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.ORCID 0000-0001-7768-746X

Funding

Austrian Science Fund (FWF) P32778Austrian Science Fund (FWF) P32947Austrian Science Fund (FWF) P33283Austrian Science Fund (FWF) P34884Austrian Science Fund (FWF) W1250 NanoCellMax-Planck-Gesellschaft (MPG) NA
6 · The paper itself

Abstract

Stromal interaction molecule 1 (STIM1) is a Ca

Indexed as

Neoplasm ProteinsProtein MultimerizationStromal Interaction Molecule 1CalciumDimerizationEndoplasmic ReticulumHumansLipid BilayersMolecular Dynamics SimulationCalciumLipid BilayersNeoplasm ProteinsSTIM1 protein, humanStromal Interaction Molecule 1STIM1store-operated calcium entryTM-helix dimerizationtransition path sampling

Identifiers

PMID40857319
PMCPMC12415195

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.