ArticleJournal of agricultural and food chemistry2025
Fingerprinting the Intestinal Transport of Low-Molecular-Mass Advanced Glycation End-Products (AGEs) Using a Caco-2 Transwell Model.
Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Transepithelial Transport and Transport Pathways of Free and Bound Nε-Carboxymethyllysine Using a Caco-2 Cell Monolayer Model.Foods (Basel, Switzerland) · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Food-borne advanced glycation end-products could potentially contribute to the endogenous AGE accumulation within the body, albeit to a different extent for different AGEs. This study focuses on characterizing intestinal absorption and intracellular accumulation of 10 selected free low-molecular-mass (LMM) advanced glycation end-products (AGEs) to obtain insight into potential differences in their systemic bioavailability by using a Caco-2 transwell model. The findings reveal that all tested AGEs can cross the intestinal barrier through the paracellular route, albeit to a limited extent. Glycolic acid-lysine-amide (GALA) shows the highest transport percentage, reaching 1.1% ± 0.3% after 2 h, while N-ε-(carboxymethyl)lysine (CML) displays the highest level of accumulation in intestinal cells, reaching 3.5% ± 0.6%. In contrast, cross-linked AGEs appeared to be hardly absorbed or accumulating. Passive transport likely dominates the intestinal uptake of LMM AGEs, with quantitative structure activity relationships based on maximum projection area and molar refractivity or on maximum projection area and molecular mass best describing their uptake rate. This study provides novel insights into differences in bioavailability and intracellular accumulation of LMM AGEs and the potential for fingerprinting their intestinal transport by a new approach methodology.
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Registered trials
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