Evidence map›Paper›PMID 40857102›Full record

ArticleJournal of medicinal chemistry2025

Repurposing Drug Metabolites into Dual β-Adrenergic Receptor-Carbonic Anhydrase Modulators as Potential Tools for Ocular Disorders.

Andrea Ammara, Alessandra Carone, Laura Lucarini, Silvia Sgambellone, Silvia Marri, Serafina Villano, Rosanna Matucci, Gerta Luga, Chiara Fittipaldi, Riccardo Pecori and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Andrea AmmaraNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence 50019, Italy.ORCID 0000-0001-7364-1499
Alessandra CaroneNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence 50019, Italy.
Laura LucariniDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, Florence 50139, Italy.
Silvia SgambelloneDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, Florence 50139, Italy.
Silvia MarriDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, Florence 50139, Italy.
Serafina VillanoDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, Florence 50139, Italy.
Rosanna MatucciDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, Florence 50139, Italy.
Gerta LugaDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, Florence 50139, Italy.
Chiara FittipaldiDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, Florence 50139, Italy.
Riccardo PecoriGerman Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.ORCID 0000-0001-9052-4075
Giuseppe PieracciniDepartment of Health Sciences, CISM Mass Spectrometry Centre, University of Florence, Viale Gaetano Pieraccini 6, Florence 50139, Italy.
Claudia Di SerioExperimental and Clinical Medicine Department, Geriatric Intensive Care Unit, University of Florence, Azienda Ospedaliera Universitaria Careggi, Viale Gaetano Pieraccini 6, Florence 50139, Italy.
Andrea García-LlorcaDepartment of Physiology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavík 101, Iceland.ORCID 0000-0001-8137-1513
Thor EysteinssonDepartment of Physiology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavík 101, Iceland.
Stanislav KalininSchool of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonrinne 3, Kuopio 70211, Finland.
Julius Aleksi Olavi ViitaSchool of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonrinne 3, Kuopio 70211, Finland.ORCID 0009-0001-6627-7251
Arto UrttiSchool of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonrinne 3, Kuopio 70211, Finland.
Fabrizio CartaNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence 50019, Italy.ORCID 0000-0002-1141-6146
Silvia SelleriNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence 50019, Italy.
Claudiu T SupuranNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence 50019, Italy.ORCID 0000-0003-4262-0323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the regioselective chemical derivatization of (

Indexed as

Adrenergic beta-3 Receptor AgonistsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesDrug RepositioningAnimalsHumansIntraocular PressureMaleOcular HypertensionRabbitsStructure-Activity RelationshipSwineAdrenergic beta-3 Receptor AgonistsCarbonic Anhydrase InhibitorsCarbonic Anhydrases

Identifiers

PMID40857102
PMCPMC12434671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.