ArticleEpilepsia2025
Association between enlarged perivascular space (ePVS) density and stereo-electroencephalography (SEEG) biomarkers of epileptogenicity.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
objectiveWe aim to explore the association between enlarged perivascular space (ePVS) density and stereo-electroencephalography (SEEG) biomarkers of epileptogenicity.
methodsWe retrospectively analyzed consecutive SEEG patients from an Australian site. We automatically segmented ePVSs from 3T pre-SEEG T1-weighted magnetic resonance imaging (MRI) scans and calculated ePVS (1) hemispheric, (2) sub-lobar, and (3) contact-level density. We defined the epileptogenic zone (EZ) SEEG contacts as those identified as the primary EZ and then selected for radiofrequency thermocoagulation (RF-TC). We classified contacts generating the top 10% of interictal epileptogenicity biomarkers (spikes, fast ripples, and cross-rates of high-frequency oscillations [HFO]*spikes). We assessed the relationship at each level for the whole cohort and its subgroups: MRI-negative-only, different voxel sizes (.9 mm
resultsFrom 53 RF-TC patients, ePVS density was not associated with the EZ at the hemispheric (p = .995), sub-lobar (p = .090), or contact (p = .999) level in the whole cohort. In the MRI-negative-only subgroup and 1.0 mm SIGNIFICANCE: ePVS density may not be a consistent biomarker of SEEG-defined epileptogenicity. The relationship between reduced ePVS and epileptogenicity in MRI-negative cases warrants further study, as this may shed light on underlying pathobiology and EZ biomarkers. Different imaging techniques may be able to capture the relationship between the glymphatic system disruption and epileptogenicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.