Evidence map›Paper›PMID 40856899›Full record

ArticleAnnals of nuclear medicine2025

SPECT reconstruction using preprocessing masking for extra-cardiac uptake versus standard processing in

Keiko Tanimoto, Yoshifumi Kawamura, Satoshi Kimura, Yumi Hasuike, Erina Tachibana, Ayako Kudo, Tadao Aikawa, Koji Murakami, Shinichiro Fujimoto

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keiko TanimotoDepartment of Radiology, Juntendo University Hospital, 3-1-3 Hongo Bunkyo-Ku, Tokyo, 113-8431, Japan. k-tanimoto@juntendo.ac.jp.
Yoshifumi KawamuraDepartment of Radiology, Juntendo University Hospital, 3-1-3 Hongo Bunkyo-Ku, Tokyo, 113-8431, Japan.
Satoshi KimuraDepartment of Radiology, Juntendo University Hospital, 3-1-3 Hongo Bunkyo-Ku, Tokyo, 113-8431, Japan.
Yumi HasuikeDepartment of Radiology, Juntendo University Hospital, 3-1-3 Hongo Bunkyo-Ku, Tokyo, 113-8431, Japan.
Erina TachibanaDepartment of Radiology, Juntendo University Hospital, 3-1-3 Hongo Bunkyo-Ku, Tokyo, 113-8431, Japan.
Ayako KudoDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Tadao AikawaDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Koji MurakamiDepartment of Radiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Shinichiro FujimotoDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn

methodsThis retrospective study included 200 patients (400 scans) who underwent a one-day stress-rest protocol using

resultsThe MUS method reduced the proportion of visually unseparated cases from 15.5% to 3.5% compared with the conventional method. In phantom studies, larger extra-cardiac accumulation and closer proximity to the myocardium resulted in greater degradation of inferior wall contrast. When a distance of 2 cm was maintained between extra-cardiac accumulation and the myocardium, the effect was substantially reduced. In clinical images, the MUS method significantly improved relative contrast in the inferolateral/inferior wall at the mid-ventricular level (Wilcoxon p = 0.030) and in the inferoseptal/inferior wall at the basal level (Wilcoxon p < 0.001), while no significant improvement was observed in the basal inferolateral/inferior wall region (Wilcoxon p = 0.605).

conclusionThe MUS method demonstrated enhanced separation of extra-cardiac accumulation and improved contrast in the inferior myocardial wall compared with conventional methods. It was particularly effective in cases where extra-cardiac accumulation overlapped or closely contacted the myocardium, indicating its potential clinical utility in

Indexed as

HeartImage Processing, Computer-AssistedMyocardial Perfusion ImagingTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonAdultAgedAged, 80 and overBiological TransportFemaleHumansMaleMiddle AgedPhantoms, ImagingRetrospective StudiesTechnetium Tc 99m SestamibiExtra-cardiac accumulationImage reconstructionMyocardial perfusion SPECTOrdered subset expectation maximization with resolution recovery

Identifiers

PMID40856899

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.