ArticleMikrochimica acta2025
A novel NiCaAl-LDH@ND-COOH nanocomposite-modified electrode for highly sensitive and selective electrochemical detection of larotrectinib in pharmaceutical and biological samples.
Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A chitosan/rGO/FeRSC advances · 2026Article
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5 authors.
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Abstract
A novel electrochemical sensor based on a glassy carbon electrode (GCE) modified with a NiCaAl layered double hydroxide with carboxyl-functionalized nanodiamonds (NiCaAl-LDH@ND-COOH) was developed for the first time to enable sensitive and selective detection of larotrectinib (LARO), the first selective pan-tropomyosin receptor kinase (TRK) inhibitor used clinically for cancer treatment. The nanocomposite was synthesized by integrating NiCaAl layered double hydroxide (LDH) with carboxyl-functionalized nanodiamonds (ND-COOH), resulting in enhanced electrocatalytic performance. The individual electrochemical properties of ND-COOH and NiCaAl-LDH were systematically evaluated and compared with those of the combined nanocomposite. ND-COOH contributed high surface area, low background current, and improved conductivity, while NiCaAl-LDH offered abundant redox-active sites and high ion-exchange capacity. The NiCaAl-LDH@ND-COOH nanocomposite exhibited a synergistic enhancement in electron transfer kinetics and surface activity, as evidenced by cyclic voltammetry and impedance studies. Under optimized conditions, the sensor displayed a wide linear detection range (1.0 to 16.37 µM) and a low detection limit of 4.36 nM. It also demonstrated excellent repeatability (RSD = 1.3%), reproducibility (RSD = 1.23%), and high selectivity against common interferents. Successful application to pharmaceutical formulations, serum, and urine samples confirmed its practicality, achieving recoveries between 96.7% and 102.6%. This work provides the first electrochemical sensing platform for LARO, offering a reliable and cost-effective tool for its monitoring in clinical and pharmaceutical settings.
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