Evidence map›Paper›PMID 40856870›Full record

SynthesisCell and tissue banking2025

Efficacy of Platelet and Leukocyte Rich Fibrin (L-PRF) in the healing process and bone repair in maxillary sinus lift surgeries: a systematic review.

Élio Hitoshi Shinohara, Ilan Hudson Gomes de Santana, Mayara Rebeca Martins Viana, Edmundo Junio Rodrigues de Almeida, Anderson Jara Ferreira, José Marcos Pereira Júnior, Arthur Felipe de Brito Andrade, Fernando Kendi Horikawa, Eduardo Dias Ribeiro

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Cell and tissue banking, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Élio Hitoshi ShinoharaFederal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
Ilan Hudson Gomes de SantanaFederal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil. ilan.hudson@academico.ufpb.br.
Mayara Rebeca Martins VianaFederal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
Edmundo Junio Rodrigues de AlmeidaFederal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
Anderson Jara FerreiraFederal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
José Marcos Pereira JúniorFederal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
Arthur Felipe de Brito AndradeFederal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
Fernando Kendi HorikawaFederal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.
Eduardo Dias RibeiroFederal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sinus lift surgery is essential after pneumatization caused by loss of posterior teeth. Leukocyte-Platelet-Rich Fibrin (L-PRF) accelerates bone healing by releasing growth factors that promote angiogenesis, cell differentiation, and inflammatory modulation. To evaluate the efficacy of L-PRF in bone healing and repair in sinus lift surgeries, in addition to investigating its role in angiogenesis and inflammatory modulation. The systematic review protocol included definition of the research question, search strategy, inclusion and exclusion criteria, study types, effect measures, screening methods, and data analysis. The search resulted in 860 studies. After removal of duplicates, 704 articles remained, of which 11 met the inclusion criteria. After careful evaluation, 4 studies were considered highly relevant and included in the systematic review. Evidence indicates that the combination of L-PRF with bone grafts, such as DBBM, can accelerate bone formation and allow early implant placement, supported by increased expression of protein markers essential for osteogenesis. The addition of L-PRF to DBBM demonstrated significant benefits in promoting a more favorable bone environment, reducing the time required for osseointegration.

Indexed as

Blood PlateletsBone RegenerationFibrinLeukocytesMaxillary SinusSinus Floor AugmentationWound HealingHumansOsteogenesisPlatelet-Rich FibrinFibrinAlveolar bone graftBone matrixLeukocyte-rich platelet fibrin (L-PRF)Sinus liftTreatment outcome

Identifiers

PMID40856870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.