Evidence map›Paper›PMID 40856832›Full record

ArticleActa neurochirurgica2025

Asymmetric efficacy of VNS within a single patient with bilateral focal frontal lobe epilepsy: A case report.

Masanobu Kumon, Shunsuke Nakae, Daijiro Kojima, Noeru Kawase, Yuichi Hirose

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Masanobu KumonDepartment of Neurosurgery, Fujita Health University Hospital School of Medicine, Aichi, Japan.
Shunsuke NakaeDepartment of Neurosurgery, Fujita Health University Hospital School of Medicine, Aichi, Japan. fujita.epi.4@gmail.com.
Daijiro KojimaDepartment of Neurosurgery, Fujita Health University Hospital School of Medicine, Aichi, Japan.
Noeru KawaseDepartment of Neurosurgery, Fujita Health University Hospital School of Medicine, Aichi, Japan.
Yuichi HiroseDepartment of Neurosurgery, Fujita Health University Hospital School of Medicine, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lateralized efficacy of vagus nerve stimulation (VNS) remains insufficiently explored. We report a case of drug-resistant epilepsy with bilateral frontal lobe seizure onset, treated with left cervical VNS. Preoperative video- electroencephalogram revealed predominant interictal discharges in the right hemisphere and frequent seizures from both hemispheres. Following VNS, overall seizure frequency decreased. Notably, stereo-electroencephalography performed 15 months postoperatively showed a marked reduction in right-sided seizures, while left-sided seizures remained frequent. This case highlights the potential lateralized effect of VNS in a single patient with bilateral frontal lobe epilepsy, suggesting that VNS may preferentially suppress seizures originating from the right hemisphere.

Indexed as

Drug Resistant EpilepsyEpilepsy, Frontal LobeFunctional LateralityVagus Nerve StimulationAdultElectroencephalographyFemaleFrontal LobeHumansMaleTreatment OutcomeDrug-resistant epilepsyLateralized efficacyStereo-electroencephalographyVagus nerve stimulation

Identifiers

PMID40856832
PMCPMC12380960

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.