ArticleInvestigative ophthalmology & visual science2025
Hyperglycemia-Reduced Platelet-Derived Growth Factor-BB Expression Impairs Corneal Wound Healing in Diabetic Mice.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices.International journal of molecular sciences · 2026Review
- Recent advances and challenges in hydrogel-based delivery of immunomodulatory strategies for diabetic wound healing.Theranostics · 2026Review
- Repair of Corneal Epithelial Defects.Progress in molecular and subcellular biology · 2026Review
- Platelet-Derived Growth Factor Isoform Imbalance Is Associated with Innate Inflammation and Corneal Epitheliopathy in Dry Eye Disease.Ophthalmic research · 2026Article
- Does Diabetes Matter? The Efficacy of PRP on the Quality of Life in Stress Urinary Incontinence.Bioengineering (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study investigates the role and primary mechanisms of platelet-derived growth factor-BB (PDGF-BB) in regulating corneal epithelial injury repair and nerve regeneration under diabetic conditions. Methods: Type 1 diabetes was induced in C57BL/6 mice via streptozotocin injection. Platelet depletion was achieved using an anti-mouse GPIbα antibody. Platelet levels were quantified in intra- and extravascular compartments of the corneal limbus. Concentrations of growth factors released by activated platelets were measured in human and murine diabetic and nondiabetic samples. Diabetic mice with corneal epithelial wounds received PDGF-BB eye drops alone or combined with ERK1/2 or AKT inhibitors. Platelet-depleted mice were treated with PDGF-BB eye drops, while wild-type C57BL/6 mice received subconjunctival anti-PDGF-BB antibody injections. Human primary corneal limbal epithelial stem cells (HLECs) from diabetic and nondiabetic donors were treated with anti-PDGF-BB antibodies or PDGF-BB small interfering RNA. Results: Diabetic individuals exhibited reduced peripheral blood platelet counts and diminished PDGF-BB expression following platelet activation. Both platelet depletion and hyperglycemia impaired corneal epithelial repair and nerve regeneration, correlating with reduced PDGF-BB levels. Inhibiting PDGF-BB signaling significantly delayed corneal epithelial healing and nerve regeneration in wild-type mice. In vitro, PDGF-BB enhanced HLEC migration and proliferation. PDGF-BB promoted corneal epithelial repair and nerve regeneration in diabetic mice via ERK1/2 and AKT pathway activation. Conclusions: Hyperglycemia suppresses PDGF-BB expression, impairing corneal epithelial wound healing and nerve regeneration by inhibiting ERK1/2 and AKT signaling. PDGF-BB may represent a potential therapeutic strategy for diabetic keratopathy.
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