ArticleAmerican journal of clinical pathology2025
Technical features and analytical performances of the Stago Expert Preanalytical Check module for hemolysis, icterus, and lipemia measurement.
Article in American journal of clinical pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Performance evaluation of Stago sthemO 301 hemostasis analyzer for routine testing, coagulation factors, and inhibitors.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2026Article
- Simulation Study on Preanalytical Variables in Coagulation Testing: Interference Effects and Threshold Determination of Hemolysis, Lipemia, Icterus and Insufficient Sample Volume.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
5 authors.
Funding
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Abstract
objectiveInterference caused by hemolysis, icterus, and lipemia (HIL) are a common source of preanalytical errors during coagulation testing. Stago has developed a specific module on its coagulation analyzers to standardize the detection of HIL.
methodsThe aims of this study were to evaluate the accuracy, carryover, and cross-interference of HIL measurement and compare results with those obtained on cobas 8000 modular analyzer series devices (Roche Diagnostics). These evaluations were carried out using Clinical and Laboratory Standards Institute guidance and regulatory study requirements.
resultsWe demonstrated the absence of sample carryover through the HIL measurement chamber and excellent accuracy between HIL theoretical and measured concentrations, with an R2 above 0.99 in all cases. We did not detect any cross-interference of bilirubin and lipids to hemoglobin, of hemoglobin and lipids to bilirubin, or for hemoglobin and bilirubin to lipids. We found excellent agreement between HIL on the Stago STA R Max3 and cobas 8000 platforms, with κ coefficients ranging from 0.928 to 0.963.
conclusionsThese results support the implementation of the Stago Expert Preanalytical Check module for HIL interference measurement in routine coagulation laboratory testing.
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