ArticleJournal of acquired immune deficiency syndromes (1999)2025
Effects of Treating Obstructive Sleep Apnea on Common Symptoms of HIV.
David L Berry, Jeremy E Orr, Christopher N Schmickl, Pamela DeYoung, Naa-Oye Bosompra, Sonia Ancoli-Israel, Igor Grant, Maile Young-Karris, Atul Malhotra, Robert L Owens
Abstract read
In one paragraphArticle in Journal of acquired immune deficiency syndromes (1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
David L BerryDivision of Pulmonary Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA.
Jeremy E OrrDivision of Pulmonary Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA.
Christopher N SchmicklDivision of Pulmonary Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA.
Pamela DeYoungDivision of Pulmonary Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA.
Naa-Oye BosompraDivision of Pulmonary Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA.
Sonia Ancoli-IsraelPsychiatry, University of California, San Diego, CA; and.
Igor GrantPsychiatry, University of California, San Diego, CA; and.
Maile Young-KarrisInfectious Diseases & Global Public Health, University of California, San Diego, CA.
Atul MalhotraDivision of Pulmonary Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA.
Robert L OwensDivision of Pulmonary Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA.ORCID 0000-0002-6515-6204 Funding
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3MVirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4MSan Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7MIs Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7MUnderlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4MSleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3MThe cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1MVentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9MObstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living with HIVR01HL142114 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR, OWENS, ROBERT LLEWELLYN · 2018 to 2021
$2.0MDeveloping a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6MAcetazolamide to Improve Clinically Important Outcomes in Obstructive Sleep Apnea Patients with a High Loop Gain EndotypeK23HL161336 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christopher Nikolaus Schmickl · 2022 to 2026
$863kThe Impact of Sleep Disordered Breathing in People who use OpioidsK23HL151880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ORR, JEREMY ELLIOT · 2021 to 2025
$849kAmerican Heart Association-American Stroke Association 940501NCATS NIH HHS UL1 TR000100NCATS NIH HHS UL1 TR001442NHLBI NIH HHS K23 HL151880NHLBI NIH HHS K23 HL161336NHLBI NIH HHS R01 HL142114NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIAID NIH HHS P30 AI036214NIA NIH HHS R01 AG063925
6 · The paper itselfAbstract
backgroundEven with modern therapy, people living with HIV (PLWH) commonly experience fatigue and face increased risk of cardiovascular disease. Obstructive sleep apnea (OSA) is common in PLWH and might contribute to these symptoms, yet the impact of OSA treatment in this population is underinvestigated.
settingAcademic university-affiliated HIV and sleep medicine clinics.
methodsOne hundred twenty PLWH underwent polysomnography and completed questionnaires measuring fatigue, daytime sleepiness, perception of cognitive functioning, and sleep quality. Those with OSA were offered positive airway pressure (PAP) therapy. All measurements were repeated after 12 weeks of treatment. Cardiovascular outcome markers included peripheral arterial tonometry (reactive hyperemia index), heart rate, and blood pressure.
resultsSeventy persons had OSA and 41 (59%) elected to use PAP. Participants demonstrated a mean (secure digital) age of 52.8 (8.8) years, 39 men, mean body mass index 28.2 (3.9) kg/m 2 , and apnea hypopnea index 4% 33.5 (26.1). PAP therapy was associated with statistically ( P < 0.05) and clinically significant improvements in fatigue [pre 39 (27 to 44) vs. post 42 (32 to 48)], reactive hyperemia index [1.6 (1.4 to 2.2) vs. 2.1 (1.7 to 2.7)], and heart rate [73 (64 to 80.50) vs. 68 (61 to 73) beats per minute]. Daytime sleepiness, sleep quality, and perception of cognitive functioning all showed improvement ( P < 0.05), although changes were clinically modest.
conclusionsTreatment of OSA in PLWH can improve fatigue and markers of cardiovascular health, consistent with PAP treatment of OSA in non-PLWH populations. Our findings support assessment and treatment of OSA in PLWH to address commonly experienced symptoms.
Indexed as
HIV InfectionsSleep Apnea, ObstructiveAdultContinuous Positive Airway PressureFatigueFemaleHeart RateHumansMaleMiddle AgedPolysomnographySurveys and QuestionnairesfatigueHIVobstructive sleep apneasleepiness
Identifiers
PMID40856602
PMCPMC12673500
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