ArticleAnnals of medicine2025
Exploring the interplay between pain processing mechanisms, psychosocial factors, and functional outcomes in patients with chronic low back pain: an exploratory study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of Telerehabilitation for Chronic Nonspecific Low Back Pain: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Comparative effectiveness of non-pharmacological interventions for depression and anxiety in chronic low back pain: a Bayesian network meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Characterising Pain in Post-COVID-19 Syndrome: An Observational Study of Intensity and Sensitivity.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundChronic low back pain (CLBP) is a prevalent condition associated with disability and increased health service usage. Understanding the interrelationship between central pain processing mechanisms, psychological factors, and functional outcomes in patients with CLBP may enhance their clinical assessment and treatment. This present study aimed to explore correlations between pain intensity and pain processing mechanisms (quantitative sensory testing [QST]), psychological factors (kinesiophobia, catastrophising, and anxiety), and functional outcomes (lumbar flexion-evoked pain thresholds and functional capacity) in individuals with CLBP.
methodsIn this exploratory study we recruited 50 patients with CLBP from a tertiary hospital in Valencia, Spain. Pain processing mechanisms were assessed using QST parameters (pressure pain threshold [PPT], temporal summation [TS], and conditioned pain modulation [CPM]). Psychological factors were measured through validated scales and functional outcomes were assessed
resultsPain intensity was significantly associated with reduced PPT, low CPM, slower STS60 performance, and elevated kinesiophobia, catastrophising, and anxiety levels (
conclusionPain intensity in patients with CLBP correlates with central sensitisation, psychological distress, and functional limitations. PPT and STS60 may serve as valuable clinical indicators of pain severity and functional impairment, respectively. These findings support a multidimensional assessment framework for CLBP, integrating sensory, psychological, and functional factors to inform comprehensive treatment strategies.
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