Evidence map›Paper›PMID 40856441›Full record

ArticlePsychological medicine2025

Affective dynamics and emotional reactivity in social anxiety disorder.

Beth Foote, Femke Lamers, Mike Xiao, Lihong Cui, Vadim Zipunnikov, Mathilde M Husky, Kathleen R Merikangas

Abstract read
In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Anxiolytic Effects ofInternational journal of general medicine · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Beth FooteDepartment of Psychology, George Mason University, Fairfax, VA, USA.ORCID 0000-0002-1759-3338
Femke LamersDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID 0000-0003-4344-5766
Mike XiaoChild Mind Institute, New York, USA.ORCID 0000-0002-9860-8238
Lihong CuiGenetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.ORCID 0000-0003-3228-467X
Vadim ZipunnikovDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-9864-2420
Mathilde M HuskyBordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.ORCID 0000-0001-5314-1403
Kathleen R MerikangasGenetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.ORCID 0000-0002-4667-2414

Funding

Family Study of Affective and Anxiety Spectrum DisordersZIAMH002804 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MERIKANGAS, KATHLEEN R · 2009 to 2025
$37.5M
Motor Activity Research Consortium for Health (mMarch)ZIAMH002954 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MERIKANGAS, KATHLEEN R · 2016 to 2025
$10.1M
Intramural NIH HHS ZIA MH002804Intramural NIH HHS ZIA MH002954
6 · The paper itself

Abstract

backgroundAlthough heightened anxiety associated with social interaction or evaluation is the core diagnostic criterion for social anxiety disorder (SAD), there is growing evidence that SAD is characterized by more pervasive reactivity beyond social situations. We employed Ecological Momentary Assessment (EMA) to describe the affective dynamics and emotional reactivity to daily events in a community-based sample of adults with SAD compared with other anxiety disorders, and controls without anxiety or mood disorders.

methodsA sample of 236 adults with a lifetime diagnosis of SAD (n = 53), other anxiety disorders (n = 120), and no mood or anxiety disorder (n = 63) based on comprehensive diagnostic interviews answered brief electronic interviews that assessed daily life events and mood and anxiety symptoms four times a day for two weeks. Linear mixed models were used to quantify reactivity to daily life events.

resultsPersons with SAD had higher average levels of sad and anxious mood than those with other anxiety disorders or controls. Irrespective of comorbid mood disorders, people with SAD also demonstrated significantly greater decreases in both sad and anxious mood following positive events, and a greater increase in anxious mood following negative, particularly non-social events.

conclusionsOur findings regarding pervasive reactivity beyond the social context in people with SAD confirm the need for broader conceptualization of this disorder as well as expansion of interventions beyond the social context. This work also demonstrates the utility of EMA as a powerful tool to track individual variability and reactivity in daily life that can inform etiology, treatment and prevention.

Indexed as

AffectAnxiety DisordersEmotionsPhobia, SocialAdultEcological Momentary AssessmentFemaleHumansMaleMiddle AgedYoung Adultaffective dynamicsEcological Momentary Assessmenteventsreactivitysocial anxiety disorder

Identifiers

PMID40856441
PMCPMC12404326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.