Evidence map›Paper›PMID 40856421›Full record

ArticleCancer medicine2025

Risk Factor and Prediction Model for Malignant Transformation in Pancreatic Intraductal Papillary Mucinous Neoplasm.

Dujiang Yang, Xijiao Liu, Mao Li, Zhenlu Li, Nengwen Ke, Junjie Xiong

Abstract read
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dujiang YangDivision of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.
Xijiao LiuDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, China.
Mao LiDivision of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zhenlu LiDivision of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.
Nengwen KeDivision of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-7135-2244
Junjie XiongDivision of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-1928-4272

Funding

Sichuan Provincial Science and Technology Support Program 2024NSFSC0740Sichuan Provincial Youth Science and Technology Foundation 2024NSFSC1683
6 · The paper itself

Abstract

purposePancreatic intraductal papillary mucinous neoplasms (IPMN) are precursors to pancreatic cancer, with an increasing incidence due to advances in imaging techniques. This study aimed to identify risk factors for malignant transformation in IPMN and develop a predictive model using data from a large medical center in western China.

methodsPatients with IPMN admitted to West China Hospital between January 2010 and February 2022 were included in this study. They were divided into benign and malignant. Characteristic parameters and laboratory results were collected. The training set and test set were randomly divided at a ratio of 7:3. Least absolute shrinkage and selection operator regression was used to select potential prognostic factors. A nomogram was developed by logistic regression. Receiver operating characteristic curves and calibration curves were used to evaluate the model's predictive performance.

resultsWe retrospectively analyzed 182 patients, identifying six independent predictors of malignancy: classification, cyst wall thickening, abrupt changes in main pancreatic duct caliber, maximum tumor diameter, maximum main pancreatic duct diameter, and lnCA19-9. We developed a nomogram with an area under the curve of 0.86 in the training set and 0.81 in the test set. The model showed strong predictive ability, providing a valuable tool for clinicians to guide preoperative decision-making.

conclusionOur study offers the first predictive model for malignant IPMN in western China and highlights the importance of comprehensive risk assessment, incorporating clinical, imaging, and laboratory data.

Indexed as

Adenocarcinoma, MucinousCarcinoma, Pancreatic DuctalCell Transformation, NeoplasticPancreatic Intraductal NeoplasmsPancreatic NeoplasmsAgedChinaFemaleHumansMaleMiddle AgedNomogramsPrognosisRetrospective StudiesRisk FactorsROC Curveintraductal papillary mucinous neoplasmnomogramprediction modelrisk factor

Identifiers

PMID40856421
PMCPMC12378654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.