Evidence map›Paper›PMID 40856386›Full record

ArticleTechnology in cancer research & treatment

Evaluating T1/T2 Relaxometry with OCRA Tabletop MRI System in Fresh Clinical Samples: Preliminary Insights into ZEB1-Associated Tissue Characteristics.

Ahmed Y Sanin, Marcus Prier, Thomas Wartmann, Christian Siba, Katrin Hippe, Maciej Pech, Roland S Croner, Oliver Speck, Ulf D Kahlert, Georg Rose

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Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahmed Y SaninMolecular and Experimental Surgery, Medical Faculty University Hospital Magdeburg, University Clinic for General, Visceral, Vascular and Transplantation Surgery, Otto-von Guericke University, Magdeburg, Germany.ORCID 0009-0009-7786-2200
Marcus PrierResearch Campus STIMULATE, Otto-von Guericke University, Magdeburg, Germany.
Thomas WartmannMolecular and Experimental Surgery, Medical Faculty University Hospital Magdeburg, University Clinic for General, Visceral, Vascular and Transplantation Surgery, Otto-von Guericke University, Magdeburg, Germany.
Christian SibaMolecular and Experimental Surgery, Medical Faculty University Hospital Magdeburg, University Clinic for General, Visceral, Vascular and Transplantation Surgery, Otto-von Guericke University, Magdeburg, Germany.
Katrin HippeInstitute for Pathology, Otto-von Guericke University, Magdeburg, Germany.
Maciej PechResearch Campus STIMULATE, Otto-von Guericke University, Magdeburg, Germany.
Roland S CronerMolecular and Experimental Surgery, Medical Faculty University Hospital Magdeburg, University Clinic for General, Visceral, Vascular and Transplantation Surgery, Otto-von Guericke University, Magdeburg, Germany.
Oliver SpeckResearch Campus STIMULATE, Otto-von Guericke University, Magdeburg, Germany.
Ulf D KahlertMolecular and Experimental Surgery, Medical Faculty University Hospital Magdeburg, University Clinic for General, Visceral, Vascular and Transplantation Surgery, Otto-von Guericke University, Magdeburg, Germany.ORCID 0000-0002-6021-1841
Georg RoseResearch Campus STIMULATE, Otto-von Guericke University, Magdeburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionThe OCRA Tabletop MRI System is a compact, low-field (0.24T) magnetic resonance platform originally developed as an educational device to teach MR physics using chemical test tube-sized samples. Given its capabilities, we explored its diagnostic potential by performing relaxometric analysis on freshly resected human tissue specimens.MethodsMatched pairs of histologically confirmed tumor and non-tumor samples were analyzed with the OCRA MRI system to determine T1 and T2 relaxation times via NMR spectroscopy. In parallel, mRNA expression levels of ZEB1, a key transcription factor involved in WNT signaling, stem cell maintenance and tumor-stroma interactions were quantified for each sample.ResultsThe measured T1 and T2 relaxation times showed distinct profiles between tumor and non-tumor tissues. These biophysical properties were correlated with ZEB1 mRNA expression, revealing preliminary associations between tissue relaxation behavior and molecular signatures relevant to tumor microenvironment dynamics.ConclusionAlthough this pilot study does not yet confirm clinical diagnostic utility, it offers initial biophysical insights into tumor-associated tissue alterations and provides a foundation for future validation studies in larger patient cohorts.

Indexed as

Magnetic Resonance ImagingNeoplasmsZinc Finger E-box-Binding Homeobox 1Biomarkers, TumorHumansTumor MicroenvironmentBiomarkers, TumorZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1EMTMRIrelaxometrytumor microenvironment

Identifiers

PMID40856386
PMCPMC12381451

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.