ArticleExploration of neuroscience2025
Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation.
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Article in Exploration of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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8citing papers in PubMed, 1 pooled it
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8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities.Journal of nanobiotechnology · 2026Pooled it
- Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sex Differences in Depression: Adult Cytogenesis as Potential Target for Precision Psychiatry.Cells · 2026Review
- From insights to innovations: evaluating preclinical paradigms in demyelinating disease therapeutics.Lab animal · 2026Review
- Immuno-Inflammatory Mechanisms in the Chronification of Pain.Pain and therapy · 2026Review
- Smart Biosensing Nanomaterials for Alzheimer's Disease: Advances in Design and Drug Delivery Strategies to Overcome the Blood-Brain Barrier.Biosensors · 2026Review
- The Freiburg framework for multimodalFrontiers in synaptic neuroscience · 2026Article
- The role of brain mechanisms in diabetic peripheral neuropathy: recent advances and comprehensive analysis.Frontiers in cellular neuroscience · 2025Review
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Authors and funding
48 authors.
Dirk M HermannChair of Vascular Neurology, Dementia and Aging, Department of Neurology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-0198-3152
Marco BacigaluppiCenter for Molecular Cardiology, University of Zurich, 8952 Zurich, Switzerland.ORCID 0000-0002-0213-2328
Claudio L BassettiDepartment of Neurology, Medical Faculty, Inselgruppe, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-4535-0245
Gabrio BassottiDepartment of Medicine and Surgery, Perugia University School of Medicine, 06132 Perugia, Italy.ORCID 0000-0002-0237-1812
Johannes BoltzeSchool of Life Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0000-0003-3956-4164
Andrew ChanDepartment of Neurology, Medical Faculty, Inselgruppe, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-3434-7283
Turgay DalkaraDepartment of Neuroscience, Bilkent University, 06800 Ankara, Turkey.ORCID 0000-0003-3943-7819
Adam DenesLaboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, H-1083 Budapest, Hungary.ORCID 0000-0001-6919-4905
Exuperio Diez-TejedorDepartment of Neurology, IdiPAZ, La Paz University Hospital, Universidad Autonoma de Madrid, 28046 Madrid, Spain.ORCID 0000-0003-2295-1707
Richard DodelDepartment of Geriatrics, University of Duisburg-Essen, 45141 Essen, Germany.ORCID 0000-0003-2044-6299
Thorsten R DoeppnerChair of Vascular Neurology, Dementia and Aging, Department of Neurology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-1222-9211
Egor DzyubenkoChair of Vascular Neurology, Dementia and Aging, Department of Neurology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0001-6901-2163
Ayman ElAliDepartment of Psychiatry and Neuroscience, Université Laval, Quebec City, QC G1V 4G2, Canada.ORCID 0000-0002-4048-6039
Tamas FulopDepartments of Medicine and Radiology and Nuclear Medicine, Université de Sherbrooke, Sherbrooke, QC J1H 5H3, Canada.ORCID 0000-0001-5835-7449
Alexander GerhardCenter for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-8071-6062
Bernd GiebelInstitute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-2446-948X
Janine GronewoldChair of Vascular Neurology, Dementia and Aging, Department of Neurology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-1470-424X
Matthias GunzerInstitute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-5534-6055
Thomas HeinbockelDepartment of Anatomy, College of Medicine, Howard University, Washington, DC 20059, U.S.A.ORCID 0000-0003-4347-2131
Kaibin HuangDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China.ORCID 0000-0002-3360-7031
Marcello IritiDepartment of Biomedical, Surgical and Dental Sciences, Milan State University, 20122 Milan, Italy.ORCID 0000-0002-5063-1236
Hans-Otto KarnathDepartment of Neurology, Eberhard Karls University Tübingen, 72074 Tübingen, Germany.ORCID 0000-0002-5518-405X
Kasteleijn-Nolst TreniteBrain Center, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands.ORCID 0000-0002-6659-2614
Ertugrul KilicDepartment of Physiology, Istanbul Medeniyet University, 34700 Istanbul, Turkey.ORCID 0000-0001-6494-8923
Giuseppe LanzaDepartment of Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5659-662X
Arthur LieszInstitute of Stroke and Dementia Research, Ludwig Maximilians University Munich, 81377 Munich, Germany.ORCID 0000-0002-9069-2594
Tim Ullrich MagnusDepartment of Neurology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-6232-9555
Jessica MandrioliDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-9244-9782
Ayan Mohamud-YusufChair of Vascular Neurology, Dementia and Aging, Department of Neurology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0001-6863-7612
Thomas MüllerDepartment of Neurology, St. Joseph Hospital Berlin-Weißensee, 13088 Berlin, Germany.ORCID 0000-0002-6799-0753
Suyue PanDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China.ORCID 0000-0003-2744-1984
Luca Peruzzotti-JamettiDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0PY Cambridge, UK.ORCID 0000-0002-9396-5607
Stefano PluchinoDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0PY Cambridge, UK.ORCID 0000-0002-6267-9472
Ryszard PlutaDepartment of Pathophysiology, Medical University of Lublin, 20-090 Lublin, Poland.ORCID 0000-0003-0764-1356
Aurel Popa-WagnerChair of Vascular Neurology, Dementia and Aging, Department of Neurology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-4574-8605
Ameneh RezayofDepartment of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran 14155-6465, Iran.ORCID 0000-0002-2806-2057
Mohamed L SeghierBiomedical Engineering & Biotechnology Department, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates.ORCID 0000-0002-1146-8800
Xinhua ShuDepartments of Biological and Biomedical Sciences and Vision Science, Glasgow Caledonian University, G4 0BA Scotland, UK.ORCID 0000-0003-3760-3019
Vikram SinghChair of Vascular Neurology, Dementia and Aging, Department of Neurology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-7361-8317
Jussi SipiläDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0003-0183-9054
Mark SlevinCenter for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania.ORCID 0000-0003-3767-4861
Yamei TangDepartment of Neurology, Brain Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong, China.ORCID 0000-0002-6353-6107
Georgios TsivgoulisSecond Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-0640-3797
Giustino VarrassiFondazione Paolo Procacci, 00193 Roma, Italy.ORCID 0000-0002-3822-2923
Chen WangChair of Vascular Neurology, Dementia and Aging, Department of Neurology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-0213-9642
Bayram YilmazDepartment of Physiology, Faculty of Medicine, Dokuz Eylul University, 35220 Izmir, Turkiye.ORCID 0000-0002-2674-6535
Maha S ZakiDepartment of Clinical Genetics, Human Genetics and Genome Research Institute, National Research Centre, Cairo 12622, Egypt.ORCID 0000-0001-7840-0002
Jinwei ZhangState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.ORCID 0000-0001-8683-509X
Funding
SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6MNIAID NIH HHS P30 AI117970
Abstract
Recent progress in translational neuroscience has significantly advanced our understanding of neurological diseases. Research progress closely went in line with innovations in research methods, which have expanded our insights considerably beyond previous limits. However, despite the development of disease-modifying treatments, therapeutic options in brain diseases still lag behind fundamental discoveries in basic neuroscience. This perspective examines the factors that hinder clinical progress in translational neuroscience and provides solutions on how to overcome them. Editorial board members of
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Clinical endpointexperimental modelsneurological therapypharmacological therapytranslation bottlenecktranslation concept
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