Photocatalyzed C(sp

Allanah B Wood, Natsuki Mizuno, Sarah Jung, Alexander W Schuppe

Abstract read

In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Allanah B WoodDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.

Natsuki MizunoDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.

Sarah JungDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.

Alexander W SchuppeDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-6002-9110

Funding

Synthesis and Modification of Natural Products through Inert Bond Cleavage ReactionsR35GM156918 · NIGMS · VANDERBILT UNIVERSITY · PI Alexander W. Schuppe · 2025 to 2026

$792k

NIGMS NIH HHS R35 GM156918

6 · The paper itself

Abstract

We report a Mizoroki-Heck reaction enabled by the visible-light-induced Pd-catalyzed C-N bond cleavage of isonitriles. Through a one-carbon activation of amines, we eliminated the need for atom-inefficient activating groups, thereby allowing isonitriles to serve as alkyl radical precursors. The utility of this protocol was demonstrated with a variety of (hetero)aromatic-containing isonitriles and differentially substituted vinyl arenes. This transformation expands the range of cross-coupling reactions that amine precursors can undergo.

Identifiers

PMID40856147

DOI10.1021/acs.orglett.5c02954

PMCPMC12418498

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.