Evidence map›Paper›PMID 40855949›Full record

ArticleAnalytical chemistry2025

To Spray or To Sublimate: Considerations for the Matrix Application of Three Common Positive Ion Mode Matrices.

Ian Spears, Gabriella Lagdameo, Alyson Black, Dalton R Brown, Cole C Johnson, Tae-Hun Hahm, Wanyue Wang, Alain Creissen, Kristine Glunde, Caitlin M Tressler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. MALDI spatial proteomics: a mini review of approaches and techniques.Analytical methods : advancing methods and applications · 2026
    Review
  5. ExploringFrontiers in cell and developmental biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ian SpearsThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center; Division of Cancer Imaging Research; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine; Baltimore, Maryland, 21205, United States.
Gabriella LagdameoThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center; Division of Cancer Imaging Research; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine; Baltimore, Maryland, 21205, United States.
Alyson BlackHTX Technologies, LLC, Chapel Hill, North Carolina, 27516, United States.
Dalton R BrownThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center; Division of Cancer Imaging Research; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine; Baltimore, Maryland, 21205, United States.
Cole C JohnsonThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center; Division of Cancer Imaging Research; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine; Baltimore, Maryland, 21205, United States.
Tae-Hun HahmThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center; Division of Cancer Imaging Research; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine; Baltimore, Maryland, 21205, United States.
Wanyue WangThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center; Division of Cancer Imaging Research; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine; Baltimore, Maryland, 21205, United States.
Alain CreissenHTX Technologies, LLC, Chapel Hill, North Carolina, 27516, United States.
Kristine GlundeThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center; Division of Cancer Imaging Research; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine; Baltimore, Maryland, 21205, United States.ORCID 0000-0002-5067-2724
Caitlin M TresslerThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center; Division of Cancer Imaging Research; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine; Baltimore, Maryland, 21205, United States.ORCID 0000-0001-9152-8123

Funding

MALDI Imaging of Acute Organophosphate Exposure in KIKO MiceR01NS136102 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Caitlin Tressler · 2024 to 2026
$1.4M
timsTOF fleX with MALDI-2 for Advanced Mass Spectrometry ImagingS10OD030500 · OD · JOHNS HOPKINS UNIVERSITY · PI GLUNDE, KRISTINE · 2021 to 2021
$1.3M
NIH HHS S10 OD030500NINDS NIH HHS R01 NS136102
6 · The paper itself

Abstract

Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is a powerful tool for imaging lipids, proteins,

Indexed as

LipidsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAnimalsBrainCoumaric AcidsGentisatesMice2,5-dihydroxybenzoic acidalpha-cyano-4-hydroxycinnamateCoumaric AcidsGentisatesLipids

Identifiers

PMID40855949
PMCPMC12424017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.