ArticleThe Australasian journal of dermatology2025
Effectiveness of Biologic Therapy in Hidradenitis Suppurativa: Real-World Clinical Outcomes and Lipid Profile Evaluation.
Article in The Australasian journal of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Decreased HDL-C in hidradenitis suppurativa: association with systemic inflammatory phenotype and implications for risk stratification.Lipids in health and disease · 2026Article
- Microbial species in deep tissue lesions of Hurley stage III hidradenitis suppurativa: a retrospective observational study.BMC microbiology · 2026Observational
- Efficacy of Secukinumab in Chinese Patients with Moderate-to-Severe Hidradenitis Suppurativa: A 16-Week, Single-Center, Prospective, Real-World Study.Journal of inflammation research · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin disease with systemic implications. While biologic therapies have demonstrated efficacy in controlling cutaneous lesions, their systemic effects, particularly on lipid metabolism as a marker of systemic inflammation, are less understood.
objectivesTo evaluate the impact of biologic therapy on clinical severity and lipid profiles in HS patients in a real-world setting, comparing outcomes between Early and Late Responders at Week 24 ± 4.
methodsTwenty-four patients with moderate-to-severe HS on biologic therapy were monitored prospectively at Baseline, Week 24 ± 4, Week 52 and Week 104. Clinical parameters (IHS4, A/N, HS-IGA) and lipid profiles (cholesterol, triglycerides) were analysed. Patients were categorised as Early (IHS4 ≤ 10) or Late Responders (IHS4 ≥ 11) at Week 24 ± 4. Statistical analysis included t-tests; significance was set at p < 0.05.
resultsEarly Responders showed significant clinical improvement and reductions in lipid levels, suggesting a systemic anti-inflammatory effect of therapy. However, lipid reductions did not reach statistical significance (p > 0.05); likely due to the small sample size. Late Responders demonstrated less pronounced changes.
conclusionsBiologic therapy appears to improve both clinical and systemic inflammatory markers in HS, highlighting the value of metabolic monitoring in routine care.
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