Evidence map›Paper›PMID 40855900›Full record

ArticleNature reviews bioengineering2025

Developing sex-accurate cell culture environments.

Alexandra N Borelli, Kristyn S Masters

Abstract read
In one paragraph

Article in Nature reviews bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Advances in application of hydrogels for treatment of osteonecrosis of the femoral head].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexandra N BorelliDepartment of Bioengineering, University of Colorado Denver|Anschutz Medical Campus, Aurora, CO, USA.
Kristyn S MastersDepartment of Bioengineering, University of Colorado Denver|Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-6911-3116

Funding

Engineered models of age-related biochemical, biophysical, and hormonal changes to elucidate mechanisms of aortic valve disease onsetR01HL172046 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KRISTYN S MASTERS · 2024 to 2026
$1.4M
NHLBI NIH HHS R01 HL172046
6 · The paper itself

Abstract

The extracellular matrix remains under-recognized as a sex-dependent entity. Designing culture environments that account for sex as a biological variable requires considering not only cellular sex, but also the usage of sex-specific scaffolds to create a holistically sex-accurate platform.

Identifiers

PMID40855900
PMCPMC12376987

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.