Evidence map›Paper›PMID 40855874›Full record

ArticleEndocrines2022

Serum IL-1ra Is Associated with but Has No Genetic Link to Type 1 Diabetes.

Paul M H Tran, Fran Dong, Khaled Bin Satter, Katherine P Richardson, Roshni Patel, Lynn K H Tran, Diane Hopkins, Ravindra Kolhe, Kathleen Waugh, Marian Rewers and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paul M H TranCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA.ORCID 0000-0003-2197-4376
Fran DongBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Mail Stop A-140, 1775 Aurora Court, Aurora, CO 80045, USA.
Khaled Bin SatterCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA.ORCID 0000-0002-2344-3002
Katherine P RichardsonCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA.
Roshni PatelCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA.
Lynn K H TranCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA.
Diane HopkinsCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA.
Ravindra KolheDepartment of Pathology, Augusta University, 1120 15th St., Augusta, GA 30912, USA.ORCID 0000-0002-8283-2403
Kathleen WaughBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Mail Stop A-140, 1775 Aurora Court, Aurora, CO 80045, USA.
Marian RewersBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Mail Stop A-140, 1775 Aurora Court, Aurora, CO 80045, USA.
Sharad PurohitCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA.ORCID 0000-0003-0385-3829

Funding

University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Natural History of Pre-Diabetic Autoimmunity (DAISY)R01DK032493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 1986 to 2024
$9.3M
Deep Learning Based Genetic Risk Prediction for Type 1 DiabetesF30DK121461 · NIDDK · AUGUSTA UNIVERSITY · PI TRAN, PAUL · 2019 to 2021
$123k
NIDDK NIH HHS F30 DK121461NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK032493
6 · The paper itself

Abstract

Interleukin-1 antagonism is a proposed biomarker and potential therapy for the delay and/or treatment of type 1 diabetes (T1D). We evaluated the role of circulating interleukin-1 receptor antagonist (IL-1ra) in a prospectively monitored cohort of T1D patients. In order to determine a mechanistic association between IL-1ra and T1D, we performed co-localization analyses between serum IL-1ra protein quantitative trait loci and T1D genome-wide analysis studies. Adjusting for human leukocyte antigen (HLA) genotypes, first degree relative status, gender, and age, serum levels of IL-1ra were lower in subjects who progressed to T1D compared to the controls (

Indexed as

biomarkerscytokinesIL-1 antagonismIL-1rainflammationtype-1 diabetes

Identifiers

PMID40855874
PMCPMC12377138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.