Evidence map›Paper›PMID 40855858›Full record

ArticleClinical psychological science : a journal of the Association for Psychological Science2025

Mechanisms of Change in Exposure Therapy for Anxiety and Related Disorders: A Research Agenda.

Kristen Benito, Andre Pittig, Jonathan Abramowitz, Joanna J Arch, Denise Chavira, Rianne de Kleine, Alessandro S De Nadai, Dirk Hermans, Stefan G Hofmann, Jürgen Hoyer and 12 more

Abstract read
In one paragraph

Article in Clinical psychological science : a journal of the Association for Psychological Science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kristen BenitoBrown University Warren Alpert Medical School, Psychiatry and Human Behavior, Providence, RI, US.
Andre PittigGeorg-August-Universität Göttingen, Georg-Elias-Mueller-Institute of Psychology, Gottingen, Niedersachsen, DE.
Jonathan AbramowitzThe University of North Carolina at Chapel Hill, Psychology, Chapel Hill, NC, US.
Joanna J ArchUniversity of Colorado at Boulder, Department of Psychology and Neuroscience, Boulder, CO, US.
Denise ChaviraUniversity of California Los Angeles, Psychology, Los Angeles, CA, US.
Rianne de KleineLeiden University, Institute of Psychology, Leiden, NL.
Alessandro S De NadaiMcLean Hospital, Harvard Medical School, Belmont, MA, US.
Dirk HermansKU Leuven, Center for the Psychology of Learning and Experimental Psychopathology, Leuven, BE.
Stefan G HofmannPhilipps-Universität Marburg, Department of Psychology, Marburg, Hessen, DE.
Jürgen HoyerTechnische Universität Dresden, Clinical Psychology and Psychotherapy, Dresden, DE.
Jonathan D HuppertThe Hebrew University of Jerusalem, Psychology, Jerusalem, IL.
Katharina KircanskiNIMH, Emotion and Development Branch, Bethesda, MD, US.
Peter M McEvoyCentre for Clinical Interventions, Centre for Clinical Interventions, AU.
Heidi MeyerBoston University, Psychological and Brain Sciences, Boston, MA, US.
Marie-H MonfilsThe University of Texas at Austin, Research and Operations, Austin, TX, US.
Santiago PapiniKaiser Permanente, Division of Research, Oakland, CA, US.
Winfried RiefPhilipps-Universität Marburg, Department of Psychology, Marburg, Hessen, DE.
David RosenfieldSouthern Methodist University, Psychology, Dallas, TX, US.
Eric A StorchBaylor College of Medicine, Psychiatry and Behavioral Sciences, Houston, TX, US.
Michael J TelchUniversity of Texas at Austin, Psychology, Austin, TX, US.
Michael W OttoBoston University, Psychology, Boston, MA, US.
Jasper A J SmitsUniversity of Texas at Austin, Psychology, Austin, TX, US.

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Columbia University Science of Behavior Change Resource and Coordinating Center renewal -Ontology Administrative SupplementU24AG052175 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EDMONDSON, DONALD · 2015 to 2024
$14.5M
Youth suicide risk: interplay of sleep behavior and circadian timing with self-critical rumination and self- reassuranceP20GM139743 · NIGMS · EMMA PENDLETON BRADLEY HOSPITAL · PI Mary A Carskadon · 2021 to 2026
$13.0M
Neuroimaging and Neuromodulation CoreP20GM130452 · NIGMS · BUTLER HOSPITAL (PROVIDENCE, RI) · PI VAN 'T WOUT-FRANK, MASCHA · 2019 to 2023
$11.3M
Effectivenss of an Integrated Treatment to Address Smoking Cessation and Anxiety/Depression in People Living with HIVR01DA047933 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI O'CLEIRIGH, CONALL MICHAEL, SMITS, JASPER · 2019 to 2023
$4.8M
1/2: CO2 Reactivity as a Biomarker of Non-response to Exposure-based TherapyR01MH125951 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Marie H. Monfils, Jasper Smits · 2022 to 2026
$3.6M
2/2-CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based TherapyR01MH125949 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Michael W. Otto · 2022 to 2026
$2.8M
Transcranial Magnetic Stimulation to Augment Exposure and Response Prevention for Pediatric OCDR61MH133666 · NIMH · EMMA PENDLETON BRADLEY HOSPITAL · PI BENITO, KRISTEN G, CONELEA, CHRISTINE A · 2023 to 2024
$2.4M
Efficacy and implementation of exercise-based smoking cessation treatment for adults with high anxiety sensitivityR01CA273221 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI MARSHALL CHENEY, Jasper Smits · 2023 to 2026
$1.8M
Quality Assessment in Exposure TherapyR01MH112516 · NIMH · EMMA PENDLETON BRADLEY HOSPITAL · PI BENITO, KRISTEN G · 2017 to 2021
$1.7M
What works for Whom in Pediatric OCDR01MH128595 · NIMH · EMMA PENDLETON BRADLEY HOSPITAL · PI BARKER, DAVID HEATON, BENITO, KRISTEN G · 2022 to 2024
$1.2M
Developmental Engagement of Neural Circuitry Underlying Safety LearningR00MH119320 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MEYER, HEIDI CATHERINE · 2022 to 2024
$747k
Intramural NIH HHS ZIA MH002781NCI NIH HHS R01 CA273221NIA NIH HHS U24 AG052175NIDA NIH HHS R01 DA047933NIDA NIH HHS R21 DA049539NIDA NIH HHS R36 DA049122NIGMS NIH HHS P20 GM130452NIGMS NIH HHS P20 GM139743NIMH NIH HHS R00 MH119320NIMH NIH HHS R01 MH112516NIMH NIH HHS R01 MH125949NIMH NIH HHS R01 MH125951NIMH NIH HHS R01 MH128595NIMH NIH HHS R61 MH133666
6 · The paper itself

Abstract

Anxiety and related disorders are a significant public health burden with rising prevalence in the wake of the COVID-19 pandemic. As demand for effective anxiety treatment increases, so too does the need for strategies to bolster treatment outcomes. Research on the mechanisms of exposure therapy, the frontline behavioral treatment, will be critically important for optimizing clinical outcomes. We outline an initial agenda for future research on the mechanisms of change of exposure therapy, developed in collaboration with a large international team of researchers through the Exposure Therapy Consortium (ETC). Key questions and recommendations for future research focus on five priority areas: conceptualization, measurement, study design/analysis, and individual/contextual differences. Rising to the challenge of addressing these questions will require coordinated action and availability of centralized tools that can be used across trials, settings, and research groups.

Indexed as

anxietyexposure therapymeasurementmechanismstreatment

Identifiers

PMID40855858
PMCPMC12373099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.