Evidence map›Paper›PMID 40855851›Full record

ArticleDystonia (Lausanne, Switzerland)2025

Neurorehabilitation in Dystonia Care: Key Questions of Who Benefits, What Modalities, and When to Intervene.

Hikaru Kamo, Koichi Nagaki, Alison R Kraus, Lisa Warren, Aparna Wagle Shukla

Abstract read
In one paragraph

Article in Dystonia (Lausanne, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Optimal physiotherapy management strategies for cervical dystonia: an international Delphi study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hikaru KamoDepartment of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, United States of America.
Koichi NagakiDepartment of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Alison R KrausDepartment of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, United States of America.
Lisa WarrenDepartment of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, United States of America.
Aparna Wagle ShuklaDepartment of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, United States of America.

Funding

Progressive resistance exercise and dystonia pathophysiology.R01NS122943 · NINDS · UNIVERSITY OF FLORIDA · PI Aparna Wagle Shukla · 2022 to 2026
$2.5M
Cerebellar and Basal Ganglia Markers Underlie Neuromotor Impairments in Adults with Autism Spectrum Disorder (ASD)R01NS121120 · NINDS · UNIVERSITY OF FLORIDA · PI WANG, ZHENG · 2021 to 2025
$1.9M
NINDS NIH HHS R01 NS121120NINDS NIH HHS R01 NS122943
6 · The paper itself

Abstract

Dystonia causes involuntary, patterned movements and posturing, often leading to disability, pain, and reduced quality-of-life. Despite standard treatments such as botulinum toxin (BoNT) injections, oral medications, and deep brain stimulation therapy, many patients continue to experience persistent symptoms. There is growing evidence supporting the use of rehabilitation-based therapies in the management of certain forms of dystonia. This review summarizes the current body of evidence, which primarily focuses on cervical dystonia (CD) and task-specific dystonia (TSD). The greatest therapeutic potential appears to lie in using these interventions as adjuncts to BoNT therapy. In CD, physical therapy has shown effectiveness when aimed at reducing overactivity in the affected neck muscles through techniques such as stretching, massage, and biofeedback. Concurrently, strengthening the opposing muscle groups helps promote improved posture, reduce pain, and enhance range of motion. In TSD, many studies applied splinting of unaffected body parts (sensory-motor retuning) to encourage adaptive retraining of affected body parts (principles of constraint-induced movement therapy), or alternatively restricting movements of affected body parts to promote sensory reorganization. Although there is high risk of bias, neuroplasticity-based strategies like motor and sensorimotor training appear to be promising for TSD. Use of kinesiotaping, vibrotactile stimulation, TENS, and orthotics can help modify movement patterns, while biofeedback can reinforce and sustain motor control improvements. Emerging evidence for functional dystonia supports the role of multimodal approach, combining PT with cognitive behavioral therapy or mind-body strategies. The focus is movement retraining to shift attention away from abnormal movements and restore confidence in normal movement to improve outcomes. Regardless of dystonia type, individualized therapy plans are essential. Home-based exercises play a critical role in maintaining the gains achieved during supervised sessions, supporting ongoing progress, and preventing regression.

Indexed as

cervical dystoniacognitive behavioral therapyexercise therapyfunctional dystoniaimmobilizationmind-body programphysical therapyRehabilitationsensory motor retuningsystematic reviewtask-specific dystonia

Identifiers

PMID40855851
PMCPMC12376834

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.