ArticleACS applied bio materials2025
Theranostic Gold Nanoparticles Encapsulated in a PEGylated Liposome as an Effective Radiosensitizer for Cancer Radiation Therapy.
Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Steering spherical nucleic acids over metabolic organs for improved targeted drug delivery.Journal of nanobiotechnology · 2026Review
- Tumor radiosensitization with gold nanoparticles: evolving strategies to improve tumoral gold uptake and catalyze future clinical translation.ACS nano medicine · 2026Article
- Targetable Biomimetic NIR-II Theranostic Nanoplatform for Highly Efficient Multimodal Imaging-Guided Photothermal Therapy of Cervical Cancer.International journal of nanomedicine · 2026Article
- Laser-Ablated Gold Nanoparticles as Tunable Contrast Agents for Preclinical Imaging.Nanomaterials (Basel, Switzerland) · 2025Article
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Authors and funding
11 authors.
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Abstract
High-Z materials enhance radiation dose deposition primarily through strong photoelectric absorption. Leveraging this property, nanoparticles based on high-Z content materials can be utilized as nanoscale radiosensitizers to enhance the efficacy of radiotherapy. Notably, gold nanoparticles (Au: gold, AuNPs) have been intensively investigated due to their excellent radiosensitizing effect and straightforward synthesis process. However, without additional modifications, they suffer from unfavorable biodistribution and inefficient tumor targeting, which limit their efficacy as radiosensitizers. Herein, we developed ultrasmall AuNPs encapsulated in PEGylated liposome (PEG: polyethylene glycol, Au-Lipo) and optimized their PEGylated lipid composition to improve their performance as radiosensitizers. Au-Lipo formulation was synthesized and optimized to exhibit good stability and cellular uptake
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