ArticleBMC infectious diseases2025
Plasma exosomal miR-122-5p_R-1, miR-23b-3p_R + 1, and miR-15a-5p_R-1 are associated with multidrug-resistant tuberculosis.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Identification of Potential Exosomal miRNA-mRNA Regulatory Network Relevant to Tuberculous-Associated Lung Cancer.Biomedicines · 2026Article
- Role of Exosomes During Mycobacterium Tuberculosis Infection: A Double-Edged Sword.Biomedicines · 2026Review
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10 authors.
Funding
Abstract
backgroundPatients with multidrug-resistant tuberculosis (MDR-TB) who are resistant to at least both rifampicin and isoniazid, lack effective treatment options in clinic. The gold standard for the diagnosis of MDR-TB is drug sensitivity test, which is time-consuming and has a relatively low positive detection rate. Screening early diagnostic biomarker for MDR-TB is urgent need in clinical practice.
methodsA total of 33 patients with MDR-TB, healthy controls and drug-sensitive tuberculosis (DS-TB) were included in this study. Total plasma exosomal RNA was extracted from the subjects, and the MDR-TB plasma-specific exosomal miRNAs were obtained by Illumina sequencing.
resultsThere were 644 and 647 differentially expressed miRNAs in the plasma exosomes of MDR-TB patients obtained by sequencing and biogenic analysis compared with DS-TB patients and healthy controls, respectively. Differential miRNAs are mainly involved in the biological function of regulation of transcription and protein binding, and enriched in the pathways in cancer and MAPK signaling pathway. Moreover, seven plasma exosomal miRNAs in MDR-TB patients were significantly different from those in DS-TB patients and healthy controls. Among them, three of the miRNAs (hsa-miR-122-5p_R-1, hsa-miR-23b-3p_R + 1, and hsa-miR-15a-5p_R-1) were found to be in target relationship with MDR-TB related genes (NTRK2, KIDINS220, NCKAP1, MAPK9, NFAT5, ATF6 and SLC11A2) by target gene prediction analysis. Further the bioinformatic analysis showed that hsa-miR-122-5p_R-1 targets the protein PGLYRP2, a diagnostic biomarker identified in our previous study.
conclusionsWe suggest that hsa-miR-122-5p_R-1, hsa-miR-23b-3p_R + 1, and hsa-miR-15a-5p_R-1 are closely related to MDR-TB.
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