ArticleBMC veterinary research2025
Molecular epidemiology and emerging genotypes of canine distemper virus in Istanbul, Türkiye.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCanine distemper virus (CDV) is a highly contagious, globally distributed pathogen that remains a serious concern even with available vaccines. In Türkiye, reports of CDV outbreaks among vaccinated dogs suggest the emergence of genetically divergent strains. This study investigated CDV prevalence, clinical correlations, molecular characteristics, and phylogenetic relationships in Istanbul, Türkiye, using rectal swabs from 202 clinically ill dogs (2018–2023).
resultsResults revealed a 27.2% infection rate (55/202), with significantly higher prevalence in puppies (< 6 months; p < 0.05). Clinical signs (fever, seizures, gastrointestinal distress) and hematological alterations (elevated neutrophils, reduced RBC counts) were strongly associated with infection (p < 0.05). Phylogenetic analysis of the hemagglutinin (H) gene revealed three circulating genotypes: Arctic-like (72%), Asia 1 (24%), and Europe (4%). Arctic-like strains clustered with Turkish and European variants, while Asia 1 strains closely matched Chinese lineages suggesting multiple introduction routes. Notably, amino acid substitutions in antigenic regions and glycosylation sites were identified, that may facilitate immune evasion, particularly concerning given Türkiye’s complex dog population dynamics.
conclusionOur findings indicate the Arctic-like CDV lineage now dominates in Istanbul’s canine population. This study provides valuable insights into the epidemiology and genetic diversity of circulating CDV genotypes in Türkiye and its implications for vaccine efficacy. Continuous surveillance is critical to monitor emerging strains and optimize control strategies.
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