Evidence map›Paper›PMID 40855474›Full record

SynthesisColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2025

Perineal salvage surgery for prolapse of ileal pouch anal anastomosis: Systematic review and meta-analysis.

Emeka Ray-Offor, Zoe Garoufalia, Sameh Hany Emile, Peter Rogers, Nir Horesh, Rachel Gefen, Peige Zhou, Giovanna DaSilva, Victor Strassmann, Steven D Wexner

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Perineal salvage surgery for prolapse of ileal pouch anal anastomosis: Systematic review and meta-analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emeka Ray-OfforEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.ORCID https://orcid.org/0000-0002-6795-6408
Zoe GaroufaliaEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.
Sameh Hany EmileEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.ORCID https://orcid.org/0000-0001-7854-5244
Peter RogersEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.
Nir HoreshEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.
Rachel GefenEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.ORCID https://orcid.org/0000-0002-8501-131X
Peige ZhouEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.
Giovanna DaSilvaEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.ORCID https://orcid.org/0000-0001-7143-324X
Victor StrassmannEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.
Steven D WexnerEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.ORCID https://orcid.org/0000-0001-8046-5753

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIleal pouch anal anastomosis (IPAA) prolapse is a rare mechanical complication, with a paucity of literature on frequency and management. This study aimed to assess the prevalence and management outcomes of perineal salvage procedures (SPs) for IPAA prolapse.

methodsSystematic search conducted in PubMed and Scopus with an additional search of relevant cross-referenced literature on experimental and observational human studies involving IPAA for ulcerative colitis or familial adenomatous polyposis from database inception to March 2023. Risk of bias assessment was performed using the NIH quality assessment tool for observational cohort and cross-sectional studies. Meta-analysis was performed by standard methodology using a random-effect model. Main outcome measure was the success rate of perineal SPs for pouch prolapse.

resultsSeventy-two publications were screened; 3 observational studies met the inclusion criteria. Included studies comprised 27,061 patients who underwent IPAAs over a 37-year study period. Ninety-five patients had IPAA prolapse and pooled prevalence of 0.4% (95% CI: 0.3-0.4; I

conclusionStudies were heterogeneous. Perineal SPs were infrequently performed for the uncommon IPAA complication of prolapse, with good outcomes in mucosal prolapse. There is insufficient evidence on functional status and quality of life following perineal SPs for full-thickness prolapse.

Indexed as

Colonic PouchesPerineumPostoperative ComplicationsProctocolectomy, RestorativeSalvage TherapyAdenomatous Polyposis ColiAdultColitis, UlcerativeFemaleHumansMaleProlapseTreatment Outcomeileal pouch anal anastomosismeta‐analysisperinealprolapsesalvagesurgerysystematic review

Identifiers

PMID40855474
PMCPMC12379049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.