ArticleBMC gastroenterology2025
Investigating the relationship between Helicobacter pylori and intestinal Clostridioides difficile infection: evidence from a cross-sectional study.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease.Frontiers in cellular and infection microbiology · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori (H. pylori) infection in the stomach can lead to alterations in the gut microbiota. However, the association between H. pylori infection and Clostridioides difficile infection (CDI) remains unclear.
methodsWe conducted a retrospective cross-sectional study to evaluate the association between H. pylori infection and CDI. We included patients hospitalized for diarrhea at our center between 2019 and 2024 who underwent both H. pylori and CDI testing during their hospital stay. H. pylori infection was diagnosed using either the carbon-13 urea breath test or the rapid urease test. CDI was diagnosed using a two-step testing algorithm. Patients were categorized into H. pylori-positive and -negative groups. We compared the prevalence of CDI between groups and assessed the association using logistic regression. To adjust for potential confounders, propensity score matching (PSM) was performed, followed by further analysis.
resultsWe included 1,624 patients: 732 H. pylori-positive and 892 H. pylori-negative. The prevalence of CDI was significantly higher in the H. pylori-positive group (13.7%, 95% CI: 11.2%-16.2%) compared to the H. pylori-negative group (9.0%, 95% CI: 7.1%-10.8%) (P = 0.003). Univariate logistic regression showed that H. pylori infection was associated with CDI (OR: 1.606, 95% CI: 1.176–2.194; P = 0.003). Multivariate analysis also suggested that H. pylori infection was independently associated with CDI (OR: 1.817, 95% CI: 1.320–2.501; P < 0.001). This association remained significant after PSM.
conclusionsOur findings suggest that current H. pylori infection may be associated with Clostridioides difficile infection.
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