ArticleSystematic reviews2025
Hepatitis B reactivation with TNF-α inhibitors: assessing antiviral prophylaxis efficacy - protocol for systematic review and meta-analysis.
Article in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hepatitis B Virus Reactivation Risk With IL-17, IL-23/IL-12, or JAK Inhibitors: A Systematic Review and Meta-Analysis.Liver international : official journal of the International Association for the Study of the Liver · 2026Pooled it
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe widespread use of TNF-α inhibitors (infliximab, adalimumab, golimumab, certolizumab pegol, and etanercept) in gastrointestinal, rheumatologic, and dermatologic disorders raises concerns about hepatitis B reactivation (HBVr). The exact risk remains unclear due to the variability in previous meta-analyses. This study aims to assess the effectiveness of antiviral prophylaxis in preventing HBV reactivation in patients on TNF-α therapy and to investigate the associated reactivation risk.
methodA systematic review adhering to PRISMA guidelines will be conducted. Comprehensive searches of electronic databases (MEDLINE via PubMed, Google Scholar, CENTRAL, and ClinicalTrials.gov) will identify relevant studies. Eligible studies will include patients with a hepatitis B infection treated with anti-TNF-α therapy. The efficacy of antiviral prophylaxis will be assessed using risk ratios (RR) with 95% confidence intervals (CI) in a random-effects model that controls for variation among trials. Heterogeneity will be evaluated using the I DISCUSSION: The rate of hepatitis B virus (HBV) reactivation varies greatly between chronic and occult carrier states. Despite established practice standards, high-risk individuals still get insufficient preventative antiviral treatment. Current recommendations propose prophylactic nucleoside/nucleotide analogue (NA) prophylaxis for immunosuppressive treatment that has a high risk of reactivating HBV. For low-risk treatments, on-demand NA treatment is recommended. For intermediate-risk drugs, either strategy might be suitable. However, there is an urgent need for agreement on standardized criteria and reporting protocols for HBV reactivation in the setting of immunosuppressive treatments. TRIAL REGISTRATION: Systematic review registration: PROSPERO CRD42024548106.
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