Evidence map›Paper›PMID 40855423›Full record

ArticleJournal of nanobiotechnology2025

Injured renal cell membrane encapsulated ICG/CORM-401 for homologous targeted NIR theranostics of acute kidney injury.

Shijie Yao, Yinan Wang, Liqiang Shao, Yang Chen, Aodi Niu, Junjia He, Weijiao Fan, Liang Xu, Bai Xu, Xiaozhou Mou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shijie YaoCenter for Rehabilitation Medicine, Rehabilitation & Sports Medicine, Department of Rehabilitation Medicine, Affiliated People's Hospital, Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Yinan WangEmergency and Critical Care Center, Intensive Care Unit, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Liqiang ShaoEmergency and Critical Care Center, Intensive Care Unit, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Yang ChenCenter for Rehabilitation Medicine, Rehabilitation & Sports Medicine, Department of Rehabilitation Medicine, Affiliated People's Hospital, Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Aodi NiuClinical Research Institute, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Junjia HeClinical Research Institute, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Weijiao FanClinical Research Institute, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Liang XuEmergency and Critical Care Center, Intensive Care Unit, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Bai XuEmergency and Critical Care Center, Intensive Care Unit, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Xiaozhou MouClinical Research Institute, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China. mouxz@zju.edu.cn.
Xianghong YangEmergency and Critical Care Center, Intensive Care Unit, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China. jyy623@163.com.
Yu CaiCenter for Rehabilitation Medicine, Rehabilitation & Sports Medicine, Department of Rehabilitation Medicine, Affiliated People's Hospital, Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China. caiyu@hmc.edu.cn.

Funding

National Natural Science Foundation of China 62205094
6 · The paper itself

Abstract

Acute kidney injury (AKI) is frequently attributed to the lack of effective early diagnosis and incorrect timing for treatment, resulting in a high incidence rate and mortality. Currently, there is no precise clinical treatment available for AKI. In this study, we developed a good approach utilizing injured renal cell membrane-coated ICG/CORM-401 nanosystem (IRICP), which can specifically target to the injured kidney site through homologous targeting of the injured renal cell membrane. Through in vivo experiments, we demonstrated that indocyanine green (ICG), acting as a near-infrared (NIR) contrast agent, enables clear visualization of its distribution using fluorescence imaging and photoacoustic imaging (PAI) techniques. The addition of CORM-401 effectively mitigates AKI-induced oxidative stress by consuming reactive oxygen species and generating carbon monoxide for anti-inflammatory, anti-apoptotic, and anti-oxidative effects, thereby effectively inhibiting the progression of AKI and facilitating its recovery. In conclusion, this targeted theranostic strategy presents high efficiency and promise potential for the future clinical treatment of AKI.

Indexed as

Acute Kidney InjuryCell MembraneIndocyanine GreenKidneyTheranostic NanomedicineAnimalsApoptosisContrast MediaHumansMaleMiceOptical ImagingOxidative StressPhotoacoustic TechniquesReactive Oxygen SpeciesContrast MediaIndocyanine GreenReactive Oxygen SpeciesAcute kidney injuryNear-infraredPhotoacoustic imagingReactive oxygen speciesRenal cell membrane

Identifiers

PMID40855423
PMCPMC12379385

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.