Survey of practices of handling exposure measurement errors in modern epidemiology: are the best practices in statistics being adopted by epidemiologists?

backgroundMeasurement errors in epidemiological studies can impact the validity and reliability of findings. Without proper context, inferences (causal or otherwise) based on these findings may be compromised. The consequences of measurement error are well known, but in practice commonly ignored when interpreting findings in epidemiological research.

methodsWe examined papers published in 2022 in three leading epidemiology journals (International Journal of Epidemiology, Epidemiology, and American Journal of Epidemiology) to assess the occurrence and handling of exposure measurement error (EME). We randomly sampled 64 papers that assessed exposure-outcome relationships. Two authors independently reviewed the selected papers and searched for (a) explicit definition of the exposure in question and how it was measured, (b) an acknowledgment of the possibility of exposure measurement error and (c) statistical investigation of the expected impact or adjustment for EME.

resultsOur review of recent epidemiological studies reveals encouraging progress on the interpretation and adjustment of EME; however, room of improvement still exists. Among our sample of 64 articles, 2 (3.1%) articles reported exposures for which measurement error did not exist, 3 (4.7%) articles lacked a well-defined research question which precluded proper classification, 8 (12.5%) articles ignored EME, 24 (37.5%) reported on EME or discussed EME as a limitation but treated it as "negligible" without investigating further, 14 (21.9%) articles conducted sensitivity analyses to describe the potential effect EME may have on the studies and 8 (12.5%) articles attempted to quantitatively estimate the impact of EME on the reported risk estimate. Further, 8 (12.5%) articles erroneously claimed that EME would bias risk estimates towards the null (2 of which were also included above).

conclusionsModern epidemiological research shows improved handling and interpretation of EME, while some concerns persist. For instance, the epidemiological literature indicates that it is still resistant to adoption of state-of-the-art methods for managing measurement errors. We recommend that the practice of qualitatively discussing the impact of measurement error in exposure in epidemiology be replaced with modern developments in statistics and comprehensively accounted for.