Evidence map›Paper›PMID 40855364›Full record

ArticleNature cell biology2025

CHIP protects lysosomes from CLN4 mutant-induced membrane damage.

Juhyung Lee, Natalie Chin, Jizhong Zou, Wan Nur Atiqah Binti Mazli, Michal Jarnik, Layla Saidi, Yue Xu, Eutteum Jeong, Jessica Suh, John Replogle and 5 more

Abstract read
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In one paragraph

Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Juhyung LeeLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3638-1496
Natalie ChinLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Jizhong ZouiPSC Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Wan Nur Atiqah Binti MazliDepartment of Chemistry and Biochemistry, the University of Maryland, College Park, MD, USA.
Michal JarnikNeurosciences and Cellular and Structural Biology Division, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1269-3508
Layla SaidiLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Yue XuLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Eutteum JeongCell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Jessica SuhTherapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
John ReplogleNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Michael E WardNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Juan S BonifacinoNeurosciences and Cellular and Structural Biology Division, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5673-6370
Wei ZhengTherapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1034-0757
Ling HaoDepartment of Chemistry and Biochemistry, the University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-0106-5266
Yihong YeLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. yihongy@mail.nih.gov.ORCID http://orcid.org/0000-0002-9512-7922

Funding

Development of Mass Spectrometry Strategies to Decipher Dynamic Lysosomal Dysfunctions in Frontotemporal DementiaR01NS121608 · NINDS · UNIV OF MARYLAND, COLLEGE PARK · PI Ling Hao · 2021 to 2026
$2.0M
U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01NS121608
6 · The paper itself

Abstract

Understanding how cells mitigate lysosomal damage is critical for unravelling pathogenic mechanisms of lysosome-related diseases. Here we generate and characterize induced pluripotent stem cell (iPSC)-derived neurons (i

Indexed as

HSP40 Heat-Shock ProteinsLysosomesMutationNeuronal Ceroid-LipofuscinosesNeuronsUbiquitin-Protein LigasesAnimalsAutophagyDrosophila melanogasterDrosophila ProteinsHumansInduced Pluripotent Stem CellsDrosophila ProteinsHSP40 Heat-Shock ProteinsSTUB1 protein, humanUbiquitin-Protein Ligases

Identifiers

PMID40855364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.