Evidence map›Paper›PMID 40855361›Full record

ArticleCommunications biology2025

Single-dose infusion of engineered viral receptor binding domain confers rapid and durable protection against viral infection.

Haiqiao Sun, Bei Tong, Deshan Ren, Ao Hu, He Li, Yixin Zhang, Shuang Liu, Xiang Duan, Zijian Zhang, Wei Liu and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Haiqiao Sun *MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210061, China.ORCID http://orcid.org/0009-0005-2573-9842
Bei Tong *Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 210014, China.ORCID http://orcid.org/0000-0002-6863-6019
Deshan Ren *MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210061, China.
Ao Hu *MOE Key Laboratory of Tropical Disease Control, Department of Immunology and Microbiology, Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510275, China.
He LiMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210061, China.
Yixin ZhangMOE Key Laboratory of Tropical Disease Control, Department of Immunology and Microbiology, Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510275, China.
Shuang LiuMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210061, China.
Xiang DuanMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210061, China.
Zijian ZhangMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210061, China.
Wei LiuMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210061, China.
Haokun YangState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Engineering Research Center of Protein and Peptide Medicine, Ministry of Education, Nanjing, 210023, China.
Jian ChenJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 210014, China.
Tunyu JianJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 210014, China.
Huanying ZhengGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, 510060, China.
Bixia KeGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, 510060, China.
Hanri ZengGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, 510060, China.
Changwen KeGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, 510060, China.
Xiaofang PengGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, 510060, China.
Yongzhen LiuMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210061, China.
Kai DengMOE Key Laboratory of Tropical Disease Control, Department of Immunology and Microbiology, Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510275, China. dengkai6@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-9973-8130
Xianchi DongState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Engineering Research Center of Protein and Peptide Medicine, Ministry of Education, Nanjing, 210023, China. xianchidong@nju.edu.cn.
Yan LiMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210061, China. yanli@nju.edu.cn.ORCID http://orcid.org/0000-0001-7612-3953

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32471000
6 · The paper itself

Abstract

Developing both rapid- and long-acting antiviral drugs for single-dose administration can improve medication adherence and protect people at risk of infection. To provide proof of this concept, here, we designed multimerized form of viral receptor-binding domains (RBDs) to immediately occupy viral receptors to block infection and subsequently induce virus-specific protective immunity. We engineered SARS-CoV-2 RBD, enhancing its affinity to ACE2 and immunogenicity through multimerization and Fc modification. A single administration of 4RBD-Fc not only effectively blocked ACE2-dependent SARS-CoV-2 infections but also elicited robust virus-specific mucosal and systemic immunity in the absence of adjuvants, providing superior early and long-lasting protection compared to adjuvanted vaccines in mice. These findings demonstrate the feasibility and efficacy of engineered viral RBD as immediate-acting and long-lasting single-dose antiviral drugs through rapid receptor blocking and ensuing adaptive immunity induction.

Indexed as

Antiviral AgentsCOVID-19Receptors, VirusSARS-CoV-2Spike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2AnimalsAntibodies, ViralCOVID-19 VaccinesFemaleHumansMiceProtein DomainsProtein EngineeringACE2 protein, humanAngiotensin-Converting Enzyme 2Antibodies, ViralAntiviral AgentsCOVID-19 VaccinesReceptors, VirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID40855361
PMCPMC12379283

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.