SynthesisEuropean journal of medical research2025
The significance of S100β and neuron-specific enolase (NSE) in postoperative cognitive dysfunction following cardiac surgery: a systematic review and meta-analysis.
Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- 14-3-3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Epilepsy as a Disorder of Neuroimmune Metabolism: The Kynurenine Pathway as a Link Between Cognitive and Psychiatric Dysfunction.Biomolecules · 2026Review
- Age-dependent cerebral oxygenation and brain injury in pediatric cardiac surgery: vulnerability of infants aged ≤6 months.Journal of intensive care · 2026Article
- Preoperative Plasma and Cerebrospinal Fluid SNAP-25 Levels Predict Delayed Neurocognitive Recovery in Elderly Patients: A Prospective Observational Study.CNS neuroscience & therapeutics · 2026Observational
- Accuracy of machine learning models for mitral regurgitation severity assessment: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- The Role of Biomarkers in Personalized Anesthesia: From Physiological Parameters to Molecular Diagnostics.Biomedicines · 2026Review
- Exosomes as a biomarker in postoperative complications: a literature review.Frontiers in cell and developmental biology · 2026Review
- Biomarkers of perioperative neurocognitive disorders after cardiac surgery: from mechanistic insights to clinical translation.Frontiers in neuroscience · 2026Review
- Effects of intravenous dexmedetomidine on hemodynamic stability, inflammatory factors, and brain injury biomarkers in patients with Moyamoya disease undergoing revascularization surgery.American journal of translational research · 2026Article
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17 authors.
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Abstract
backgroundPostoperative cognitive dysfunction (POCD) significantly affects recovery, hospitalization duration, and quality of life following cardiac surgery. Identifying reliable biomarkers for predicting POCD could improve patient outcomes and perioperative care. Among these, S100 calcium-binding protein beta (S100β) and neuron-specific enolase (NSE) have emerged as promising indicators of cerebral injury and neurocognitive dysfunction.
objectivesThis systematic review and meta-analysis aimed to assess within-subject perioperative changes in S100β and NSE levels among patients who developed POCD after cardiac surgery, to evaluate whether these biomarkers consistently rise in association with POCD.
methodsFollowing PRISMA guidelines, we searched PubMed, Scopus, and Web of Science up to October 2024. Studies included peer-reviewed articles evaluating S100β and NSE levels in relation to POCD in cardiac surgery patients. Two reviewers independently extracted data and assessed the quality using the ROBINS-I tool. Meta-analyses were conducted using a random-effects model.
resultsThirty studies were included. Among patients who developed POCD, both S100β and NSE levels were significantly elevated postoperatively compared to preoperative baselines. The pooled standardized mean difference (SMD) was 1.52 (95% CI 0.57-2.48; I
conclusionsAmong patients who developed POCD, S100β and NSE levels significantly increased from preoperative to postoperative measurements, indicating a potential association with cerebral injury. However, as non-POCD patients were not analyzed for the same biomarker changes, causality or specificity to POCD cannot be confirmed and future research should be directed toward between group changes.
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