Evidence map›Paper›PMID 40855289›Full record

ArticleLipids in health and disease2025

Adipose-specific HuR deletion protects against high-fat diet-induced obesity in mice through upregulating Ucp1 expression.

Xiuqin Fan, Yuanyuan Wang, Ping Li, Rui Wang, Tiantian Tang, Kemin Qi

Abstract read
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Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiuqin FanLaboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Yuanyuan WangLaboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Ping LiLaboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Rui WangLaboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Tiantian TangLaboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Kemin QiLaboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. qikemin@bch.com.cn.

Funding

National Natural Science Foundation of China 81800750
6 · The paper itself

Abstract

backgroundRNA-binding proteins (RBPs) have been proved to play essential roles in post-transcriptional regulation of genes associated with adipogenesis. However, the role of the RBP human antigen R (HuR) in the pathogenesis of obesity remains to be clarified.

methodsAdipocyte-specific HuR knockout (HuR

resultsAdipocyte-specific HuR deletion inhibited body weight gain with HFD feeding, being accompanied by less BAT whitening and more WAT browning, and up-regulated expressions of adipose thermogenic genes (Pgc-1α, Ucp1, etc.). HuR could bind to the 3'UTR of the Ucp1 mRNA, and thus downregulated its expression. In addition, although the HuR expression was not changed in obesity, there was an enhanced transfer of HuR protein from the nuclear to cytoplasm, thus impacting the expression of target genes including the Ucp1.

conclusionsThese findings indicate that adipose tissue-specific HuR deletion alleviates HFD-induced obesity by promoting adipose thermogenesis through upregulating Ucp1 expression.

Indexed as

ELAV-Like Protein 1ObesityUncoupling Protein 1AdipocytesAdipogenesisAdipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsDiet, High-FatMaleMiceMice, Inbred C57BLMice, KnockoutPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaThermogenesisElavl1 protein, mouseELAV-Like Protein 1Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseUcp1 protein, mouseUncoupling Protein 1Adipose tissueHuman antigen R (HuR)ObesityPost-transcriptional regulationUncoupling protein 1 (Ucp1)

Identifiers

PMID40855289
PMCPMC12376737

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