Evidence map›Paper›PMID 40855265›Full record

ArticleBMC genomics2025

Physiological and molecular regulatory mechanisms of flavonoid and hormone biosynthesis in rejuvenated the oldest ginkgo tree.

Fangdi Li, Tianhe Zhang, Rou Wan, Peishuo Jiang, Xiaoge Gao, Qirong Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Plants (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fangdi LiCollege of Forestry and Grassland College of Soil and Water Conservation, Nanjing Forestry University, Nanjing, 210037, China.
Tianhe ZhangCollege of Forestry and Grassland College of Soil and Water Conservation, Nanjing Forestry University, Nanjing, 210037, China.
Rou WanCollege of Forestry and Grassland College of Soil and Water Conservation, Nanjing Forestry University, Nanjing, 210037, China.
Peishuo JiangCollege of Forestry and Grassland College of Soil and Water Conservation, Nanjing Forestry University, Nanjing, 210037, China.
Xiaoge GaoCollege of Forestry and Grassland College of Soil and Water Conservation, Nanjing Forestry University, Nanjing, 210037, China.
Qirong GuoCollege of Forestry and Grassland College of Soil and Water Conservation, Nanjing Forestry University, Nanjing, 210037, China. qrguo@njfu.edu.cn.

Funding

he Talent Introduction Project Study of Nanjing Forestry University on Ginkgo biloba and other important tree germplasm resources GXL2018001Jiangsu Province Graduate Scientific Research and Innovation Plan Project KYCX23_1250National Natural Science Foundation of China 31971648
6 · The paper itself

Abstract

backgroundTree rejuvenation is the transition from adult state to juvenile state. Successive grafting can result in tree rejuvenation. Flavonoids constitute a prominent class of secondary metabolites that play critical roles in regulating cellular physiology, signaling, and the transduction between plant and environment interactions. Meanwhile, endogenous phytohormones are instrumental in restoring the juvenile features of trees. However, little is known about the flavonoid and hormone biosynthesis in rejuvenated Ginkgo biloba L.

resultsHere we rejuvenated the surviving 4,000-year-old Ginkgo through successive grafting. The results revealed leaf cleavage, leaf width, leaf length, and leaf area increased significantly in S

conclusionsThe comprehensive analysis of the RNA-seq, small RNA, and physiological data in this study provided candidate genes and clarified the regulatory mechanism of successive grafting in rejuvenated Ginkgo, suggesting that the number of successive generations of grafted rejuvenation should not exceed the third generation (S₃).

Indexed as

FlavonoidsGinkgo bilobaPlant Growth RegulatorsGene Expression ProfilingGene Expression Regulation, PlantPlant LeavesFlavonoidsPlant Growth RegulatorsEndogenous phytohormonesFlavonoid contentRejuvenated GinkgoRNA-seqSmall RNA

Identifiers

PMID40855265
PMCPMC12376463

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.