Evidence map›Paper›PMID 40855193›Full record

ArticleNature medicine2025

Patient-reported outcome measures add value as clinical trial endpoints.

Norah L Crossnohere, Anne L R Schuster, Jeffrey Bruckel, Ronald C Chen, Amy M Cizik, Samantha Cruz Rivera, Christopher Muth, Linda Nelsen, Derek Kyte, Albert W Wu and 3 more

Abstract read
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In one paragraph

Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Qualitative insights from patient/caregivers, and clinicians on routine use of the EQ-5D-Y-5L in clinical paediatric care-results from a pilot feasibility and acceptability trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Norah L CrossnohereDivision of General Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA. norah.crossnohere@osumc.edu.ORCID http://orcid.org/0000-0002-2811-1330
Anne L R SchusterDepartment of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-4391-1712
Jeffrey BruckelDepartment of Medicine, Division of Cardiology, University of Rochester Medical Center, Rochester, NY, USA.
Ronald C ChenDepartment of Radiation Oncology, University of Kansas Cancer Center, Kansas City, KS, USA.
Amy M CizikDepartment of Orthopedics, University of Utah, Salt Lake City, UT, USA.
Samantha Cruz RiveraCentre for Patient Reported Outcomes Research, University of Birmingham, Birmingham, UK.
Christopher MuthJournal of the American Medical Association, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-4729-7935
Linda NelsenPatient Centered Outcomes (retired), GSK, Collegeville, PA, USA.
Derek KyteSchool of Health & Wellbeing, Department of Allied Health, University of Worcester, Worcester, UK.ORCID http://orcid.org/0000-0002-7679-6741
Albert W WuJohns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6189-7120
Elissa ThornerPatient advocate, The PROTEUS Consortium, Baltimore, MD, USA.
Claire SnyderJohns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD, USA.
Michael BrundageQueen's University Cancer Research Institute, Cancer Care and Epidemiology, Kingston, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.