ArticleArchives of toxicology2025
An evaluation of the human relevance of the thyroid follicular cell tumors observed in rats treated with the synthetic fungicide, pyridachlometyl, based on mode of action.
Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In a carcinogenicity study with SD rats exposed to pyridachlometyl (dietary dose levels, 0, 200, 2000, 10,000 and 20,000 ppm), an increase in thyroid follicular cell (TFC) adenoma and/or carcinoma was observed in male rats at ≥ 2000 ppm but not in female rats. We evaluated the mode of action (MOA) of pyridachlometyl-induced TFC tumor formation and its relevance to humans. Pyridachlometyl was neither genotoxic, cytotoxic nor immunosuppressive based on a series of toxicity studies. Data from general toxicity studies suggested that the MOA involve altered homeostasis of the hypothalamic-pituitary-thyroid (HPT) axis by hepatic uridine diphosphate glucuronosyltransferase (UGT) induction. Short-term in vivo MOA studies in SD rats showed that pyridachlometyl caused T
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