Evidence map›Paper›PMID 40855182›Full record

ArticleThe Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics2025

Advance Market Commitments and Their Role in Public Innovation.

Sarosh Nagar, Anil Cacodcar, Aaron S Kesselheim

Abstract read
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In one paragraph

Article in The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarosh NagarProgram On Regulation, Therapeutics, And Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, https://ror.org/04b6nzv94Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-4534-6561
Anil Cacodcarhttps://ror.org/01mcvy510Harvard College, Cambridge, MA.
Aaron S KesselheimProgram On Regulation, Therapeutics, And Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, https://ror.org/04b6nzv94Brigham and Women's Hospital, Boston, MA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advance market commitments (AMCs) are gaining increasing attention as an alternative science funding mechanism to promote innovation in medicine. In this paper, we first review the theory underlying AMCs, before analyzing two case studies of prior AMCs: the Gavi, the Vaccine Alliance pneumococcal conjugate vaccine AMC launched in 2007 and the use of AMC-like mechanisms in Operation Warp Speed in the US. We identify the empirical successes and limitations of AMCs in promoting research and development into new therapeutics and vaccine candidates, highlighting both the strong promise of AMCs and the need to complement them with other science funding mechanisms to promote innovation. We conclude with a series of recommendations to inform science policymakers.

Indexed as

Financing, OrganizedInventionsCOVID-19 VaccinesHumansPneumococcal VaccinesUnited StatesCOVID-19 VaccinesPneumococcal VaccinesAdvance market commitmentBiomedical researchInnovation policyMetascienceScience funding

Identifiers

PMID40855182
PMCPMC12916232

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.