ArticleNature biomedical engineering2026
A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity.
Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Discovery and design of potent cell surface display elements.Nature biotechnology · 2026Article
- Delivery of mRNA Therapeutics Beyond Infectious Diseases: Design Innovations and Applications in Oncology, Cardiovascular, and Rare Genetic Diseases.Pharmaceuticals (Basel, Switzerland) · 2026Review
- A self-assembled nanoparticle vaccine displaying chimeric and trimeric RBD-HRC elicits broad-spectrum neutralizing antibodies against multiple coronaviruses.Microbiology spectrum · 2026Article
- Cross-Priming and Cross-Tolerance After Intramuscular mRNA Vaccination for Viral Infections: Feasibility and Implications.Life (Basel, Switzerland) · 2025Review
- A novel multi-epitope mRNA vaccine against colorectal cancer: in silico design and immune efficacy profiling.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Certain messenger RNA antigens in mRNA vaccines elicit an insufficient immune response due to challenges in cell surface translocation (CST) of the antigens. Here we develop a modular vaccine platform (MVP) to enhance the immunogenicity of challenging mRNA antigens by optimizing antigen expression and presentation. MVPs enable the modular assembly of chimeric antigens. Our platform comprises diverse modules capable of generating >2,500 combinations with any antigen and displaying distinct antigen epitopes on the cell surface. We quantify the CST efficacy of various modules using multiple antigens, including the mpox virus (MPXV) proteins A29, M1R and A35R, and compare chimeric antigen surface expression in multiple cell lines. Using MPXV as a model, we identify optimal modules that enhance the CST of multiple MPXV antigens, improving the immune response of lipid nanoparticle mRNAs and protecting against lethal viral challenge. With these effective CST modules, we further demonstrate the generalizability of MVP by optimizing additional mRNA antigens, including the human papillomavirus 16 proteins E6 and E7 and the varicella zoster virus glycoprotein gE. This platform is applicable to any antigen of interest, facilitating the development of mRNA vaccines against challenging targets.
Indexed as
Identifiers
40855125What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.