ArticleScientific reports2025
Identifying potential drug targets for postoperative abdominal wall hernia using Mendelian randomization: a multi-omics study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Toward precision hernia surgery: integrating biomarkers, genomics, quantitative imaging, and artificial intelligence in abdominal wall repair.Hernia : the journal of hernias and abdominal wall surgery · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to identify potential drug targets for postoperative abdominal wall hernia. Mendelian Randomization (MR) was applied to integrate data from druggable gene libraries, cis-pQTL data, and cis-eQTL data to analyze postoperative abdominal wall hernia in the FinnGen R11 population. Sensitivity and heterogeneity tests were conducted, along with reverse causality validation, to explore potential drug targets. A colocalization analysis was performed based on three cis-pQTL databases and cis-eQTL databases. Linkage disequilibrium was verified using Summary Data-Based Mendelian Randomization (SMR), and potential drug side effects were assessed using existing databases. Finally, drug target predictions and molecular docking studies were conducted. MR analysis revealed that, within the druggable target range, only one druggable gene, cathepsin S (CTSS) (FDR < 0.05; OR = 1.13, 95% CI = 1.06-1.20, P = 6.79 × 10e-5), was positively correlated with postoperative abdominal wall hernia. Colocalization analysis showed PPH4 > 0.7 in the cis-pQTL and cis-eQTL gene window of ± 50 kb. A key variant (rs41305070) was identified. Evaluation of drug side effects and molecular docking demonstrated that CTSS holds potential as a promising druggable target. Elevated levels of CTSS increase the risk of postoperative abdominal wall hernia, making CTSS a promising therapeutic target for this condition.
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