ArticleScientific reports2025
Inhibition of DJ-1 protects from lupus onset and severity.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The DJ-1 protein, known as an oxidative stress sensor, plays an important role in immunological processes. Using DJ-1 gene knock-out mice, we identified DJ-1 as a positive regulator in systemic lupus erythematosus (SLE). DJ-1 deficiency significantly alleviated skin lesion, splenomegaly, lymphadenopathy, while reducing multiple autoantibodies and immunoglobulin levels. Moreover, DJ-1 deficiency provided protection against renal hypertrophy and decreased glomerular deposition of immunoglobulin, ultimately leading to reduced albuminuria and SLE activity. These findings demonstrate that DJ-1 expression critically influences the progression of lupus-like disease.
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