Evidence map›Paper›PMID 40855031›Full record

ArticleEJNMMI physics2025

Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT and

Lorenzo Mercolli, William M Steinberger, Narendra Rathod, Maurizio Conti, Paweł Moskal, Axel Rominger, Robert Seifert, Kuangyu Shi, Ewa Ł Stępień, Hasan Sari

Erratum issuedAbstract read
In one paragraph

Article in EJNMMI physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Lorenzo MercolliDepartment of Nuclear Medicine, Inselspital, Bern University Hostpital, University of Bern, Bern, Switzerland. lorenzo.mercolli@insel.ch.ORCID http://orcid.org/0000-0002-3170-7311
William M SteinbergerSiemens Medical Solutions USA, Inc., Knoxville, TN, USA.
Narendra RathodDepartment of Nuclear Medicine, Inselspital, Bern University Hostpital, University of Bern, Bern, Switzerland.
Maurizio ContiSiemens Medical Solutions USA, Inc., Knoxville, TN, USA.
Paweł MoskalFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, Bern University Hostpital, University of Bern, Bern, Switzerland.
Robert SeifertDepartment of Nuclear Medicine, Inselspital, Bern University Hostpital, University of Bern, Bern, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Inselspital, Bern University Hostpital, University of Bern, Bern, Switzerland.
Ewa Ł StępieńFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland.
Hasan SariDepartment of Nuclear Medicine, Inselspital, Bern University Hostpital, University of Bern, Bern, Switzerland.

Funding

Narodowym Centrum Nauki 2021/42/A/ST2/00423Narodowym Centrum Nauki 2022/47/I/NZ7/03112Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 216944
6 · The paper itself

Abstract

purposeMeasuring the ortho-positronium (oPs) lifetime in human tissue bears the potential of adding clinically relevant information about the tissue microenvironment to conventional positron emission tomography (PET). Through phantom measurements, we investigate the voxel-wise measurement of oPs lifetime using a commercial long-axial field-of-view (LAFOV) PET scanner.

methodsWe prepared four samples with mixtures of Amberlite XAD4, a porous polymeric adsorbent, and water and added between 1.12 and 1.44 MBq of

resultsAmberlite XAD4 allows the preparation of samples with distinct oPs lifetime. Using a Bayesian fitting procedure, the oPs lifetimes in the whole samples are 2.52 ± 0.03 ns, 2.37 ± 0.03 ns, 2.27 ± 0.04 ns and 1.82 ± 0.02 ns, respectively. The voxel-wise oPs lifetime fits showed that even with 4.0

conclusionsOur study shows that positronium lifetime imaging on a commercial LAFOV PET/CT is feasible using

Indexed as

124ILong axial field-of-view PET/CTPositronium lifetime imaging

Identifiers

PMID40855031
PMCPMC12379202

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.